1-((2S)-(1-[4-(methoxycarbonyl)benzyl]-5-oxotetrahydro-1H-pyrrol-2-yl)methyl)-1H-imidazole-5-carboxylic acid

Base Information

Chemical Name:1-((2S)-(1-[4-(methoxycarbonyl)benzyl]-5-oxotetrahydro-1H-pyrrol-2-yl)methyl)-1H-imidazole-5-carboxylic acid
CAS No.:1308719-74-5
Molecular Formula:C₁₈H₁₉N₃O₅
Molecular Weight:357.366
Hs Code.:

Synonyms:1-((2S)-(1-[4-(methoxycarbonyl)benzyl]-5-oxotetrahydro-1H-pyrrol-2-yl)methyl)-1H-imidazole-5-carboxylic acid

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Chemical Property of 1-((2S)-(1-[4-(methoxycarbonyl)benzyl]-5-oxotetrahydro-1H-pyrrol-2-yl)methyl)-1H-imidazole-5-carboxylic acid

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Technology Process of 1-((2S)-(1-[4-(methoxycarbonyl)benzyl]-5-oxotetrahydro-1H-pyrrol-2-yl)methyl)-1H-imidazole-5-carboxylic acid

There total 10 articles about 1-((2S)-(1-[4-(methoxycarbonyl)benzyl]-5-oxotetrahydro-1H-pyrrol-2-yl)methyl)-1H-imidazole-5-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 1308719-66-5
1-[[1-[[4-(methoxycarbonyl)phenyl]methyl]-5-oxo-(2S)-pyrrolidinyl]methyl]-1H-imidazole-5-carboxylic acid phenylmethyl ester

: 1308719-74-5
1-((2S)-(1-[4-(methoxycarbonyl)benzyl]-5-oxotetrahydro-1H-pyrrol-2-yl)methyl)-1H-imidazole-5-carboxylic acid

Guidance literature:: With palladium 10% on activated carbon; hydrogen; In methanol;
DOI:10.1016/j.bmc.2011.03.044

Reference yield:

: 17342-08-4
(S)-Pyroglutaminol

: 1308719-74-5
1-((2S)-(1-[4-(methoxycarbonyl)benzyl]-5-oxotetrahydro-1H-pyrrol-2-yl)methyl)-1H-imidazole-5-carboxylic acid

Guidance literature:: Multi-step reaction with 6 steps

1.1: pyridine

2.1: sodium hydride / tetrahydrofuran; paraffin oil / 0 - 20 °C

3.1: potassium carbonate / methanol / 0.5 h / 20 °C

4.1: triethylamine / dichloromethane / 0 - 20 °C

5.1: caesium carbonate / N,N-dimethyl-formamide / 0.5 h / 50 °C / Inert atmosphere

5.2: 50 °C / Inert atmosphere

6.1: palladium 10% on activated carbon; hydrogen / methanol

With pyridine; palladium 10% on activated carbon; hydrogen; sodium hydride; potassium carbonate; caesium carbonate; triethylamine; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; paraffin oil;
DOI:10.1016/j.bmc.2011.03.044

Reference yield:

: 1308719-51-8
4-[[(2S)-[(acetyloxy)methyl]-5-oxo-1-pyrrolidinyl]methyl]benzoic acid methyl ester

: 1308719-74-5
1-((2S)-(1-[4-(methoxycarbonyl)benzyl]-5-oxotetrahydro-1H-pyrrol-2-yl)methyl)-1H-imidazole-5-carboxylic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium carbonate / methanol / 0.5 h / 20 °C

2.1: triethylamine / dichloromethane / 0 - 20 °C

3.1: caesium carbonate / N,N-dimethyl-formamide / 0.5 h / 50 °C / Inert atmosphere

3.2: 50 °C / Inert atmosphere

4.1: palladium 10% on activated carbon; hydrogen / methanol

With palladium 10% on activated carbon; hydrogen; potassium carbonate; caesium carbonate; triethylamine; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2011.03.044