1-[[1-[[4-(methoxycarbonyl)phenyl]methyl]-5-oxo-(2S)-pyrrolidinyl]methyl]-1H-imidazole-5-carboxylic acid phenylmethyl ester

Base Information

Chemical Name:1-[[1-[[4-(methoxycarbonyl)phenyl]methyl]-5-oxo-(2S)-pyrrolidinyl]methyl]-1H-imidazole-5-carboxylic acid phenylmethyl ester
CAS No.:1308719-66-5
Molecular Formula:C₂₅H₂₅N₃O₅
Molecular Weight:447.491
Hs Code.:

Synonyms:1-[[1-[[4-(methoxycarbonyl)phenyl]methyl]-5-oxo-(2S)-pyrrolidinyl]methyl]-1H-imidazole-5-carboxylic acid phenylmethyl ester

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Chemical Property of 1-[[1-[[4-(methoxycarbonyl)phenyl]methyl]-5-oxo-(2S)-pyrrolidinyl]methyl]-1H-imidazole-5-carboxylic acid phenylmethyl ester

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Technology Process of 1-[[1-[[4-(methoxycarbonyl)phenyl]methyl]-5-oxo-(2S)-pyrrolidinyl]methyl]-1H-imidazole-5-carboxylic acid phenylmethyl ester

There total 9 articles about 1-[[1-[[4-(methoxycarbonyl)phenyl]methyl]-5-oxo-(2S)-pyrrolidinyl]methyl]-1H-imidazole-5-carboxylic acid phenylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 1208114-68-4
1H-imidazole-4⁽⁵⁾-carboxylic acid phenylmethyl ester

: 1308719-58-5
4-[[(2S)-[[[(4-methylphenyl)sulfonyl]oxy]methyl]-5-oxo-1-pyrrolidinyl]methyl]benzoic acid methyl ester

: 1308719-66-5
1-[[1-[[4-(methoxycarbonyl)phenyl]methyl]-5-oxo-(2S)-pyrrolidinyl]methyl]-1H-imidazole-5-carboxylic acid phenylmethyl ester

: 1308719-79-0
1-[[1-[[4-(methoxycarbonyl)phenyl]methyl]-5-oxo-(2S)-pyrrolidinyl]methyl]-1H-imidazole-4-carboxylic acid phenylmethyl ester

Guidance literature:: 1H-imidazole-4⁽⁵⁾-carboxylic acid phenylmethyl ester; With caesium carbonate; In N,N-dimethyl-formamide; at 50 ℃; for 0.5h; Inert atmosphere;

4-[[(2S)-[[[(4-methylphenyl)sulfonyl]oxy]methyl]-5-oxo-1-pyrrolidinyl]methyl]benzoic acid methyl ester; In N,N-dimethyl-formamide; at 50 ℃; Inert atmosphere;
DOI:10.1016/j.bmc.2011.03.044

Reference yield:

: 17342-08-4
(S)-Pyroglutaminol

: 1308719-66-5
1-[[1-[[4-(methoxycarbonyl)phenyl]methyl]-5-oxo-(2S)-pyrrolidinyl]methyl]-1H-imidazole-5-carboxylic acid phenylmethyl ester

: 1308719-79-0
1-[[1-[[4-(methoxycarbonyl)phenyl]methyl]-5-oxo-(2S)-pyrrolidinyl]methyl]-1H-imidazole-4-carboxylic acid phenylmethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: pyridine

2.1: sodium hydride / tetrahydrofuran; paraffin oil / 0 - 20 °C

3.1: potassium carbonate / methanol / 0.5 h / 20 °C

4.1: triethylamine / dichloromethane / 0 - 20 °C

5.1: caesium carbonate / N,N-dimethyl-formamide / 0.5 h / 50 °C / Inert atmosphere

5.2: 50 °C / Inert atmosphere

With pyridine; sodium hydride; potassium carbonate; caesium carbonate; triethylamine; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; paraffin oil;
DOI:10.1016/j.bmc.2011.03.044

Reference yield:

: 1308719-51-8
4-[[(2S)-[(acetyloxy)methyl]-5-oxo-1-pyrrolidinyl]methyl]benzoic acid methyl ester

: 1308719-66-5
1-[[1-[[4-(methoxycarbonyl)phenyl]methyl]-5-oxo-(2S)-pyrrolidinyl]methyl]-1H-imidazole-5-carboxylic acid phenylmethyl ester

: 1308719-79-0
1-[[1-[[4-(methoxycarbonyl)phenyl]methyl]-5-oxo-(2S)-pyrrolidinyl]methyl]-1H-imidazole-4-carboxylic acid phenylmethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate / methanol / 0.5 h / 20 °C

2.1: triethylamine / dichloromethane / 0 - 20 °C

3.1: caesium carbonate / N,N-dimethyl-formamide / 0.5 h / 50 °C / Inert atmosphere

3.2: 50 °C / Inert atmosphere

With potassium carbonate; caesium carbonate; triethylamine; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2011.03.044