3-(((R)-(tert-butoxycarbonylamino)(phenyl)methyl)(hydroxy)phosphoryl)-2-(4-(thiophen-3-yl)benzyl)propanoic acid

Base Information

Chemical Name:3-(((R)-(tert-butoxycarbonylamino)(phenyl)methyl)(hydroxy)phosphoryl)-2-(4-(thiophen-3-yl)benzyl)propanoic acid
CAS No.:1206514-80-8
Molecular Formula:C₂₆H₃₀NO₆PS
Molecular Weight:515.567
Hs Code.:

Synonyms:3-(((R)-(tert-butoxycarbonylamino)(phenyl)methyl)(hydroxy)phosphoryl)-2-(4-(thiophen-3-yl)benzyl)propanoic acid

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Chemical Property of 3-(((R)-(tert-butoxycarbonylamino)(phenyl)methyl)(hydroxy)phosphoryl)-2-(4-(thiophen-3-yl)benzyl)propanoic acid

Chemical Property:

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Technology Process of 3-(((R)-(tert-butoxycarbonylamino)(phenyl)methyl)(hydroxy)phosphoryl)-2-(4-(thiophen-3-yl)benzyl)propanoic acid

There total 6 articles about 3-(((R)-(tert-butoxycarbonylamino)(phenyl)methyl)(hydroxy)phosphoryl)-2-(4-(thiophen-3-yl)benzyl)propanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: C₂₇H₃₂NO₆PS

: 1206514-80-8
3-(((R)-(tert-butoxycarbonylamino)(phenyl)methyl)(hydroxy)phosphoryl)-2-(4-(thiophen-3-yl)benzyl)propanoic acid

Guidance literature:: C₂₇H₃₂NO₆PS; With sodium hydroxide; In acetone; at 20 ℃;

With hydrogenchloride; In water;

Reference yield:

: 100-52-7
benzaldehyde

: 1206514-80-8
3-(((R)-(tert-butoxycarbonylamino)(phenyl)methyl)(hydroxy)phosphoryl)-2-(4-(thiophen-3-yl)benzyl)propanoic acid

Guidance literature:: Multi-step reaction with 8 steps

1.1: ethanol / 3 h / Reflux

2.1: hydrogenchloride; water / 2 h / Reflux

2.2: 0 h

3.1: sodium hydroxide / 1,4-dioxane / 3 h / 0 °C / pH 9.5

3.2: Cooling with ice

4.1: (R)-1-phenyl-ethyl-amine / ethyl acetate; isopropyl alcohol / Resolution of racemate

5.1: N,O-bis-(trimethylsilyl)-acetamide / 15 h / 75 °C

6.1: hydrogen bromide; acetic acid / 1 h / 20 °C

7.1: triethylamine / N,N-dimethyl-formamide / 20 °C

8.1: sodium hydroxide / acetone / 20 °C

With hydrogenchloride; N,O-bis-(trimethylsilyl)-acetamide; (R)-1-phenyl-ethyl-amine; water; hydrogen bromide; acetic acid; triethylamine; sodium hydroxide; In 1,4-dioxane; ethanol; ethyl acetate; N,N-dimethyl-formamide; isopropyl alcohol; acetone;

Reference yield:

: 106019-40-3
α-(N-benzyloxycarbonylamino)benzyl-H-phosphonous acid

: 1206514-80-8
3-(((R)-(tert-butoxycarbonylamino)(phenyl)methyl)(hydroxy)phosphoryl)-2-(4-(thiophen-3-yl)benzyl)propanoic acid

Guidance literature:: Multi-step reaction with 5 steps

1: (R)-1-phenyl-ethyl-amine / ethyl acetate; isopropyl alcohol / Resolution of racemate

2: N,O-bis-(trimethylsilyl)-acetamide / 15 h / 75 °C

3: hydrogen bromide; acetic acid / 1 h / 20 °C

4: triethylamine / N,N-dimethyl-formamide / 20 °C

5: sodium hydroxide / acetone / 20 °C

With N,O-bis-(trimethylsilyl)-acetamide; (R)-1-phenyl-ethyl-amine; hydrogen bromide; acetic acid; triethylamine; sodium hydroxide; In ethyl acetate; N,N-dimethyl-formamide; isopropyl alcohol; acetone;