Technology Process of 10-butyl-3-(4-methoxyphenyl)-7-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-10H-phenothiazine
There total 6 articles about 10-butyl-3-(4-methoxyphenyl)-7-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-10H-phenothiazine which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
3-bromo-10-butyl-7-(4-methoxyphenyl)-10H-phenothiazine;
With
n-butyllithium;
In
tetrahydrofuran; hexane;
at -78 ℃;
for 2h;
Inert atmosphere;
2-Isopropoxy-4,4,5,5-tetramethyl-1,3,2-dioxaborolane;
In
tetrahydrofuran; hexane;
at -78 - 20 ℃;
for 12h;
Inert atmosphere;
DOI:10.5012/bkcs.2012.33.2.492
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: n-butyllithium / tetrahydrofuran; hexane / 2 h / -78 °C / Inert atmosphere
1.2: 12 h / -78 - 20 °C / Inert atmosphere
2.1: tetrakis(triphenylphosphine) palladium(0); Aliquat 336; potassium carbonate / tetrahydrofuran; water / 12 h / 75 °C / Inert atmosphere
3.1: n-butyllithium / tetrahydrofuran; hexane / 2 h / -78 °C / Inert atmosphere
3.2: 12 h / -78 - 20 °C / Inert atmosphere
With
tetrakis(triphenylphosphine) palladium(0); n-butyllithium; Aliquat 336; potassium carbonate;
In
tetrahydrofuran; hexane; water;
2.1: Suzuki coupling;
DOI:10.5012/bkcs.2012.33.2.492
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: N-benzyl-N,N,N-triethylammonium chloride; sodium hydroxide / water; dimethyl sulfoxide / 0.5 h
1.2: 12 h / 20 °C
2.1: N-Bromosuccinimide / N,N-dimethyl-formamide / 5.5 h / 5 - 20 °C / Inert atmosphere
3.1: tetrakis(triphenylphosphine) palladium(0); Aliquat 336; potassium carbonate / tetrahydrofuran; water / 12 h / 75 °C / Inert atmosphere
4.1: n-butyllithium / tetrahydrofuran; hexane / 2 h / -78 °C / Inert atmosphere
4.2: 12 h / -78 - 20 °C / Inert atmosphere
With
N-Bromosuccinimide; tetrakis(triphenylphosphine) palladium(0); n-butyllithium; N-benzyl-N,N,N-triethylammonium chloride; Aliquat 336; potassium carbonate; sodium hydroxide;
In
tetrahydrofuran; hexane; water; dimethyl sulfoxide; N,N-dimethyl-formamide;
3.1: Suzuki coupling;
DOI:10.5012/bkcs.2012.33.2.492
