methyl 4-[1-({[2-(3-fluorobenzyl)-3-thienyl]carbonyl}amino)ethyl]benzoate

Base Information

• Chemical Name: methyl 4-[1-({[2-(3-fluorobenzyl)-3-thienyl]carbonyl}amino)ethyl]benzoate
• CAS No.: 1207861-06-0
• Molecular Formula: C₂₂H₂₀FNO₃S
• Molecular Weight: 397.47
• Mol file: 1207861-06-0.mol

Synonyms:methyl 4-[1-({[2-(3-fluorobenzyl)-3-thienyl]carbonyl}amino)ethyl]benzoate

Chemical Property of methyl 4-[1-({[2-(3-fluorobenzyl)-3-thienyl]carbonyl}amino)ethyl]benzoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

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Technology Process of methyl 4-[1-({[2-(3-fluorobenzyl)-3-thienyl]carbonyl}amino)ethyl]benzoate

There total 1 articles about methyl 4-[1-({[2-(3-fluorobenzyl)-3-thienyl]carbonyl}amino)ethyl]benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

(+/-)-1-[4-(methoxycarbonyl)phenyl]ethanaminium chloride (934388-45-1) + 2-(3-fluorobenzyl)thiophene-3-carboxylic acid (1207861-05-9) → methyl 4-[1-({[2-(3-fluorobenzyl)-3-thienyl]carbonyl}amino)ethyl]benzoate (1207861-06-0)

Guidance literature:

With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 0 - 20 ℃;

DOI:10.1021/jm901771h

Reference yield: 81.0%

methyl 4-[1-({[2-(3-fluorobenzyl)-3-thienyl]carbonyl}amino)ethyl]benzoate (1207861-06-0) → methyl 4-[1-({[5-chloro-2-(3-fluorobenzyl)-3-thienyl]carbonyl}amino)ethyl]benzoate (1207861-07-1)

Guidance literature:

With N-chloro-succinimide; acetic acid; In dichloromethane; at 50 ℃; for 1h;

DOI:10.1021/jm901771h

upstream raw materials:

(+/-)-1-[4-(methoxycarbonyl)phenyl]ethanaminium chloride

2-(3-fluorobenzyl)thiophene-3-carboxylic acid

Downstream raw materials:

methyl 4-[1-({[5-chloro-2-(3-fluorobenzyl)-3-thienyl]carbonyl}amino)ethyl]benzoate