2-(1,1-dideuterated-2-methylallyl)-2-(3-phenylprop-2-ynyl)malonic acid dimethyl ester

Base Information

Chemical Name:2-(1,1-dideuterated-2-methylallyl)-2-(3-phenylprop-2-ynyl)malonic acid dimethyl ester
CAS No.:1609650-46-5
Molecular Formula:C₁₈H₂₀O₄
Molecular Weight:302.339
Hs Code.:

Synonyms:2-(1,1-dideuterated-2-methylallyl)-2-(3-phenylprop-2-ynyl)malonic acid dimethyl ester

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Chemical Property of 2-(1,1-dideuterated-2-methylallyl)-2-(3-phenylprop-2-ynyl)malonic acid dimethyl ester

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Technology Process of 2-(1,1-dideuterated-2-methylallyl)-2-(3-phenylprop-2-ynyl)malonic acid dimethyl ester

There total 1 articles about 2-(1,1-dideuterated-2-methylallyl)-2-(3-phenylprop-2-ynyl)malonic acid dimethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 1431372-78-9
toluene-4-sulfonic acid 1,1-dideuterated-2-methylallyl ester

: 346621-58-7
dimethyl 2-(3-phenylprop-2-yn-1-yl)malonate

: 1609650-46-5
2-(1,1-dideuterated-2-methylallyl)-2-(3-phenylprop-2-ynyl)malonic acid dimethyl ester

Guidance literature:: dimethyl 2-(3-phenylprop-2-yn-1-yl)malonate; With sodium hydride; In tetrahydrofuran; at 0 ℃; for 0.5h; Inert atmosphere;

toluene-4-sulfonic acid 1,1-dideuterated-2-methylallyl ester; In tetrahydrofuran; at 0 - 20 ℃; for 6h; Inert atmosphere;
DOI:10.1021/ja504048u

Reference yield:

: 1609650-46-5
2-(1,1-dideuterated-2-methylallyl)-2-(3-phenylprop-2-ynyl)malonic acid dimethyl ester

: (+)-4-benzylidene-1-deuterated-5-methylbicyclo[3.1.0]hexane-2,2-dicarboxylic acid dimethyl ester

: (-)-4-benzylidene-5-methylbicyclo[3.1.0]hexane-2,2-dicarboxylic acid dimethyl ester

Guidance literature:: With (S)-((4,4’-bi-1,3-benzodioxole)-5,5’-diyl)bis(diphenylphosphine); bis(1,5-cyclooctadiene)rhodium(I) tetrafluoroborate; hydrogen; benzoic acid; In dichloromethane; 1,2-dichloro-ethane; at 80 ℃; for 16h; Overall yield = 35 %; enantioselective reaction; Schlenk technique; Inert atmosphere;
DOI:10.1021/ja504048u