(S)-3-(4-chloro-phenyl)-N₁,N₁-dimethyl-propane-1,2-diamine hydrochloride

Base Information

Chemical Name:(S)-3-(4-chloro-phenyl)-N₁,N₁-dimethyl-propane-1,2-diamine hydrochloride
CAS No.:1308662-28-3
Molecular Formula:C₁₁H₁₇ClN₂*ClH
Molecular Weight:249.183
Hs Code.:

(S)-3-(4-chloro-phenyl)-N<sub>1</sub>,N<sub>1</sub>-dimethyl-propane-1,2-diamine hydrochloride

Synonyms:(S)-3-(4-chloro-phenyl)-N₁,N₁-dimethyl-propane-1,2-diamine hydrochloride

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-3-(4-chloro-phenyl)-N₁,N₁-dimethyl-propane-1,2-diamine hydrochloride

Chemical Property:

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Technology Process of (S)-3-(4-chloro-phenyl)-N₁,N₁-dimethyl-propane-1,2-diamine hydrochloride

There total 2 articles about (S)-3-(4-chloro-phenyl)-N₁,N₁-dimethyl-propane-1,2-diamine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: (S)-2-amino-3-(4-chloro-phenyl)-N,N-dimethyl-propionamide trifluoroacetate

: 1308662-28-3
(S)-3-(4-chloro-phenyl)-N₁,N₁-dimethyl-propane-1,2-diamine hydrochloride

Guidance literature:: (S)-2-amino-3-(4-chloro-phenyl)-N,N-dimethyl-propionamide trifluoroacetate; With lithium aluminium tetrahydride; In tetrahydrofuran; for 4h; Cooling with ice; Reflux;

With sodium hydroxide; In tetrahydrofuran; ethyl acetate;

With hydrogenchloride; In diethyl ether; Inert atmosphere;

Reference yield:

: 51301-86-1,57292-44-1,129101-26-4,68090-88-0
Boc-p-chloro-L-Phe-OH

: 1308662-28-3
(S)-3-(4-chloro-phenyl)-N₁,N₁-dimethyl-propane-1,2-diamine hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1.1: N-ethyl-N,N-diisopropylamine; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / N,N-dimethyl-formamide; tetrahydrofuran / 0.67 h / 0 - 20 °C

1.2: 2 h / 20 °C

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 4 h / Cooling with ice; Reflux

2.3: Inert atmosphere

With lithium aluminium tetrahydride; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; N,N-dimethyl-formamide;

Reference yield:

: 1308662-07-8
2-(3-Formyl-benzyl)-1,1-dioxo-1λ6 isothiazolidine-3-carboxylic acid ethyl ester

: 1308662-28-3
(S)-3-(4-chloro-phenyl)-N₁,N₁-dimethyl-propane-1,2-diamine hydrochloride

: 1308662-29-4
C₂₅H₃₄ClN₃O₄S

Guidance literature:: (S)-3-(4-chloro-phenyl)-N₁,N₁-dimethyl-propane-1,2-diamine hydrochloride; With triethylamine; In methanol; for 0.166667h;

2-(3-Formyl-benzyl)-1,1-dioxo-1λ6 isothiazolidine-3-carboxylic acid ethyl ester; In methanol; at 20 ℃; for 0.25h; Inert atmosphere;

With sodium cyanoborohydride; acetic acid; In methanol; at 20 ℃; Inert atmosphere; Cooling with ice;