2-((2S,4R)-5,5-Dimethyl-2-oxo-4-phenyl-2λ⁵-[1,3,2]dioxaphosphinan-2-yl)-pyridine

Base Information

• Chemical Name: 2-((2S,4R)-5,5-Dimethyl-2-oxo-4-phenyl-2λ⁵-[1,3,2]dioxaphosphinan-2-yl)-pyridine
• CAS No.: 210910-05-7
• Molecular Formula: C₁₆H₁₈NO₃P
• Molecular Weight: 303.298

Synonyms:2-((2S,4R)-5,5-Dimethyl-2-oxo-4-phenyl-2λ⁵-[1,3,2]dioxaphosphinan-2-yl)-pyridine

Chemical Property of 2-((2S,4R)-5,5-Dimethyl-2-oxo-4-phenyl-2λ⁵-[1,3,2]dioxaphosphinan-2-yl)-pyridine

Chemical Property:

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Technology Process of 2-((2S,4R)-5,5-Dimethyl-2-oxo-4-phenyl-2λ⁵-[1,3,2]dioxaphosphinan-2-yl)-pyridine

There total 3 articles about 2-((2S,4R)-5,5-Dimethyl-2-oxo-4-phenyl-2λ⁵-[1,3,2]dioxaphosphinan-2-yl)-pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 24.0%

(S)-(+)-1-phenyl-2,2-dimethyl-1,3-propanediol (52178-66-2,98674-79-4) + 2-Pyridylphosphonsaeuredichlorid (38606-04-1) → 2-((2S,4R)-5,5-Dimethyl-2-oxo-4-phenyl-2λ5-[1,3,2]dioxaphosphinan-2-yl)-pyridine (210910-05-7) + 2-((2R,4R)-5,5-Dimethyl-2-oxo-4-phenyl-2λ5-[1,3,2]dioxaphosphinan-2-yl)-pyridine (210910-04-6)

Guidance literature:

With triethylamine; In chloroform; Ambient temperature;

DOI:10.1016/S0040-4020(98)00414-1

Reference yield:

(S)-(+)-1-phenyl-2,2-dimethyl-1,3-propanediol (52178-66-2,98674-79-4) → 2-((2S,4R)-5,5-Dimethyl-2-oxo-4-phenyl-2λ5-[1,3,2]dioxaphosphinan-2-yl)-pyridine (210910-05-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 56 percent / H₃PO₄, dicyclohexylcarbodiimide / tetrahydrofuran / 1.5 h / Ambient temperature

2: t-BuOK / tetrahydrofuran

With phosphoric acid; potassium tert-butylate; dicyclohexyl-carbodiimide; In tetrahydrofuran;

DOI:10.1016/S0040-4020(98)00414-1

Reference yield:

1-methoxy-pyridinium (30718-14-0) + (2S,4R)-5,5-Dimethyl-4-phenyl-[1,3,2]dioxaphosphinane 2-oxide (161853-73-2) → 2-((2S,4R)-5,5-Dimethyl-2-oxo-4-phenyl-2λ5-[1,3,2]dioxaphosphinan-2-yl)-pyridine (210910-05-7) + 2-((2R,4R)-5,5-Dimethyl-2-oxo-4-phenyl-2λ5-[1,3,2]dioxaphosphinan-2-yl)-pyridine (210910-04-6)

Guidance literature:

With potassium tert-butylate; In tetrahydrofuran; Yields of byproduct given;

DOI:10.1016/S0040-4020(98)00414-1

upstream raw materials:

1-methoxy-pyridinium

(2S,4R)-5,5-Dimethyl-4-phenyl-[1,3,2]dioxaphosphinane 2-oxide

(S)-(+)-1-phenyl-2,2-dimethyl-1,3-propanediol

2-Pyridylphosphonsaeuredichlorid

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