Technology Process of 6(R)-<(tert-butyldiphenylsilyl)oxy>-2(E),4(E),8(Z)-tetradecatrien-1-ol
There total 23 articles about 6(R)-<(tert-butyldiphenylsilyl)oxy>-2(E),4(E),8(Z)-tetradecatrien-1-ol which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 96 percent / imidazole / tetrahydrofuran / 8 h / 25 °C
2: 78 percent / trimethylsilyl iodide, propene / CHCl3 / 0.5 h / 25 °C
3: 90 percent / benzene / 16 h / Heating
4: 1.) NaH / 1.) benzene, 25 deg C, 1 h, 2.) benzene, 0 deg C
5: 81 percent / aluminum hydride / tetrahydrofuran / 1.5 h / 0 °C
With
1H-imidazole; aluminium hydride; propene; trimethylsilyl iodide; sodium hydride;
In
tetrahydrofuran; chloroform; benzene;
DOI:10.1021/jo00358a016
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 100 percent / hydrogen / Lindlar catalyst / benzene / Ambient temperature
2: 70 percent / (CH2SH)2, TsOH / CHCl3 / 3 h / Heating
3: 55 percent / lead tetraacetate / benzene / 1 h / Ambient temperature
4: 61 percent / benzene / 6 h / Heating
5: 60 percent / LiCl, 1,8-diazabicyclo<5.4.0>undec-7-ene / acetonitrile / 1 h / 20 °C
6: 100 percent / aluminum hydride / tetrahydrofuran / 2.5 h / 0 °C
With
aluminium hydride; lead(IV) acetate; hydrogen; toluene-4-sulfonic acid; ethane-1,2-dithiol; 1,8-diazabicyclo[5.4.0]undec-7-ene; lithium chloride;
Lindlar's catalyst;
In
tetrahydrofuran; chloroform; acetonitrile; benzene;
DOI:10.1021/jo00271a032
- Guidance literature:
-
Multi-step reaction with 8 steps
1: 87 percent / pyridine, DMAP / 25 °C
2: H2O / 120 h / 25 °C / bacteria 4-10T (Klebsiella pneumoniae)
3: 96 percent / H2, quinoline / Lindlar catalyst / ethanol / 0.67 h / 760 Torr
4: 96 percent / imidazole / tetrahydrofuran / 8 h / 25 °C
5: 78 percent / trimethylsilyl iodide, propene / CHCl3 / 0.5 h / 25 °C
6: 90 percent / benzene / 16 h / Heating
7: 1.) NaH / 1.) benzene, 25 deg C, 1 h, 2.) benzene, 0 deg C
8: 81 percent / aluminum hydride / tetrahydrofuran / 1.5 h / 0 °C
With
pyridine; 1H-imidazole; quinoline; aluminium hydride; dmap; propene; trimethylsilyl iodide; hydrogen; sodium hydride;
Lindlar's catalyst;
In
tetrahydrofuran; ethanol; chloroform; water; benzene;
DOI:10.1021/jo00358a016
