2-chloro-N-(4-(2-(hydroxymethyl)thiazol-4-yl)phenyl)-4-(methylsulfonyl)benzamide

Base Information

Chemical Name:2-chloro-N-(4-(2-(hydroxymethyl)thiazol-4-yl)phenyl)-4-(methylsulfonyl)benzamide
CAS No.:1314248-43-5
Molecular Formula:C₁₈H₁₅ClN₂O₄S₂
Molecular Weight:422.913
Hs Code.:

Synonyms:2-chloro-N-(4-(2-(hydroxymethyl)thiazol-4-yl)phenyl)-4-(methylsulfonyl)benzamide

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Chemical Property of 2-chloro-N-(4-(2-(hydroxymethyl)thiazol-4-yl)phenyl)-4-(methylsulfonyl)benzamide

Chemical Property:

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Technology Process of 2-chloro-N-(4-(2-(hydroxymethyl)thiazol-4-yl)phenyl)-4-(methylsulfonyl)benzamide

There total 3 articles about 2-chloro-N-(4-(2-(hydroxymethyl)thiazol-4-yl)phenyl)-4-(methylsulfonyl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1314250-27-5
2-chloro-(4-methylsulfonyl)-N-(4-(2-ethoxycarbonylthiazol-4-yl)phenyl)benzamide

: 1314248-43-5
2-chloro-N-(4-(2-(hydroxymethyl)thiazol-4-yl)phenyl)-4-(methylsulfonyl)benzamide

Guidance literature:: 2-chloro-(4-methylsulfonyl)-N-(4-(2-ethoxycarbonylthiazol-4-yl)phenyl)benzamide; With lithium borohydride; 2-chloro-(4-methylsulfonyl)-N-(4-(thiazol-4-yl)phenyl)benzamide; In tetrahydrofuran; at 60 ℃; for 1h; Inert atmosphere;

With water; In tetrahydrofuran;

Reference yield:

: 53101-04-5
ethyl 4-(4-nitrophenyl)-1,3-thiazole-2-carboxylate

: 1314248-43-5
2-chloro-N-(4-(2-(hydroxymethyl)thiazol-4-yl)phenyl)-4-(methylsulfonyl)benzamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: hydrogenchloride; tin(II) chloride dihdyrate / ethanol; water / 2 h / Reflux

1.2: 0 °C

1.3: 17 h

2.1: lithium borohydride; 2-chloro-(4-methylsulfonyl)-N-(4-(thiazol-4-yl)phenyl)benzamide / tetrahydrofuran / 1 h / 60 °C / Inert atmosphere

With hydrogenchloride; lithium borohydride; tin(II) chloride dihdyrate; 2-chloro-(4-methylsulfonyl)-N-(4-(thiazol-4-yl)phenyl)benzamide; In tetrahydrofuran; ethanol; water;

Reference yield:

: 99-81-0
4-Nitrophenacyl bromide

: 1314248-43-5
2-chloro-N-(4-(2-(hydroxymethyl)thiazol-4-yl)phenyl)-4-(methylsulfonyl)benzamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: ethanol / 19 h / 80 °C

2.1: hydrogenchloride; tin(II) chloride dihdyrate / ethanol; water / 2 h / Reflux

2.2: 0 °C

2.3: 17 h

3.1: lithium borohydride; 2-chloro-(4-methylsulfonyl)-N-(4-(thiazol-4-yl)phenyl)benzamide / tetrahydrofuran / 1 h / 60 °C / Inert atmosphere

With hydrogenchloride; lithium borohydride; tin(II) chloride dihdyrate; 2-chloro-(4-methylsulfonyl)-N-(4-(thiazol-4-yl)phenyl)benzamide; In tetrahydrofuran; ethanol; water;