2-chloro-(4-methylsulfonyl)-N-(4-(2-ethoxycarbonylthiazol-4-yl)phenyl)benzamide

Base Information

Chemical Name:2-chloro-(4-methylsulfonyl)-N-(4-(2-ethoxycarbonylthiazol-4-yl)phenyl)benzamide
CAS No.:1314250-27-5
Molecular Formula:C₂₀H₁₇ClN₂O₅S₂
Molecular Weight:464.95
Hs Code.:

Synonyms:2-chloro-(4-methylsulfonyl)-N-(4-(2-ethoxycarbonylthiazol-4-yl)phenyl)benzamide

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Chemical Property of 2-chloro-(4-methylsulfonyl)-N-(4-(2-ethoxycarbonylthiazol-4-yl)phenyl)benzamide

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Technology Process of 2-chloro-(4-methylsulfonyl)-N-(4-(2-ethoxycarbonylthiazol-4-yl)phenyl)benzamide

There total 2 articles about 2-chloro-(4-methylsulfonyl)-N-(4-(2-ethoxycarbonylthiazol-4-yl)phenyl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 53101-04-5
ethyl 4-(4-nitrophenyl)-1,3-thiazole-2-carboxylate

: 53250-83-2
2-chloro-4-(methanesulfonyl)benzoic acid

: 1314248-41-3
2-chloro-(4-methylsulfonyl)-N-(4-(thiazol-4-yl)phenyl)benzamide

: 1314250-27-5
2-chloro-(4-methylsulfonyl)-N-(4-(2-ethoxycarbonylthiazol-4-yl)phenyl)benzamide

Guidance literature:: ethyl 4-(4-nitrophenyl)-1,3-thiazole-2-carboxylate; With hydrogenchloride; tin(II) chloride dihdyrate; In ethanol; water; for 2h; Reflux;

With potassium hydroxide; In ethanol; water; at 0 ℃;

2-chloro-4-(methanesulfonyl)benzoic acid; With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; for 17h;

Reference yield:

: 99-81-0
4-Nitrophenacyl bromide

: 1314250-27-5
2-chloro-(4-methylsulfonyl)-N-(4-(2-ethoxycarbonylthiazol-4-yl)phenyl)benzamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: ethanol / 19 h / 80 °C

2.1: hydrogenchloride; tin(II) chloride dihdyrate / ethanol; water / 2 h / Reflux

2.2: 0 °C

2.3: 17 h

With hydrogenchloride; tin(II) chloride dihdyrate; In ethanol; water;

Reference yield: 18.0%

: 1314248-41-3
2-chloro-(4-methylsulfonyl)-N-(4-(thiazol-4-yl)phenyl)benzamide

: 1314250-27-5
2-chloro-(4-methylsulfonyl)-N-(4-(2-ethoxycarbonylthiazol-4-yl)phenyl)benzamide

: 1314248-40-2
2-chloro-N-(4-(thiazol-4-yl)phenyl)benzamide

Guidance literature:: 2-chloro-(4-methylsulfonyl)-N-(4-(thiazol-4-yl)phenyl)benzamide; 2-chloro-(4-methylsulfonyl)-N-(4-(2-ethoxycarbonylthiazol-4-yl)phenyl)benzamide; With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 ℃; for 1h; Inert atmosphere;

With hydrogenchloride; In tetrahydrofuran; water;