Ethyl [5-(2-amino-4-pyridyl)-4-(3-methylphenyl)-1,3-thiazol-2-YL]acetate

Base Information

Chemical Name:Ethyl [5-(2-amino-4-pyridyl)-4-(3-methylphenyl)-1,3-thiazol-2-YL]acetate
CAS No.:365428-80-4
Molecular Formula:C₁₉H₁₉N₃O₂S
Molecular Weight:353.445
Hs Code.:
DSSTox Substance ID:DTXSID00471115
Wikidata:Q82299539

Synonyms:ETHYL [5-(2-AMINO-4-PYRIDYL)-4-(3-METHYLPHENYL)-1,3-THIAZOL-2-YL]ACETATE;365428-80-4;DTXSID00471115;CLYDJQKXFXLHLY-UHFFFAOYSA-N;ethyl [5 (2 amino-4 pyridyl)-4 (3-methylphenyl)-1,3 thiazol-2 yl]acetate

Suppliers and Price of Ethyl [5-(2-amino-4-pyridyl)-4-(3-methylphenyl)-1,3-thiazol-2-YL]acetate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Ethyl [5-(2-amino-4-pyridyl)-4-(3-methylphenyl)-1,3-thiazol-2-YL]acetate

Chemical Property:

XLogP3:3.4
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:6
Exact Mass:353.11979803
Heavy Atom Count:25
Complexity:450

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CCOC(=O)CC1=NC(=C(S1)C2=CC(=NC=C2)N)C3=CC=CC(=C3)C

Technology Process of Ethyl [5-(2-amino-4-pyridyl)-4-(3-methylphenyl)-1,3-thiazol-2-YL]acetate

There total 5 articles about Ethyl [5-(2-amino-4-pyridyl)-4-(3-methylphenyl)-1,3-thiazol-2-YL]acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 2-(2-amino-4-pyridyl)-2-bromo-1-(3-methylphenyl)ethanone hydrobromide

: 13621-50-6
ethoxycarbonylthioacetamide

: 365428-80-4
ethyl [5-(2-amino-4-pyridyl)-4-(3-methylphenyl)-1,3-thiazol-2-yl]acetate

Guidance literature:: In N,N-dimethyl-formamide; at 20 ℃; for 14h;
DOI:10.1021/jm050165o

Reference yield:

: 303162-37-0
2-(2-tert-butoxycarbonylamino-pyridin-4-yl)-1-(3-methylphenyl)ethanone

: 365428-80-4
ethyl [5-(2-amino-4-pyridyl)-4-(3-methylphenyl)-1,3-thiazol-2-yl]acetate

Guidance literature:: Multi-step reaction with 2 steps

1: 86 percent / Br₂; AcOH / 3 h / 80 °C

2: 63 percent / dimethylformamide / 14 h / 20 °C

With bromine; acetic acid; In N,N-dimethyl-formamide;
DOI:10.1021/jm050165o

Reference yield:

: 21384-43-0
1-(3-methylbenzoyl)-2-methylaziridine

: 365428-80-4
ethyl [5-(2-amino-4-pyridyl)-4-(3-methylphenyl)-1,3-thiazol-2-yl]acetate

Guidance literature:: Multi-step reaction with 3 steps

1.1: BuLi / tetrahydrofuran; hexane / 0.5 h / 0 °C

1.2: 81 percent / tetrahydrofuran; hexane / -78 - 20 °C

2.1: 86 percent / Br₂; AcOH / 3 h / 80 °C

3.1: 63 percent / dimethylformamide / 14 h / 20 °C

With n-butyllithium; bromine; acetic acid; In tetrahydrofuran; hexane; N,N-dimethyl-formamide;
DOI:10.1021/jm050165o