(3S,4S)-4-azido-5-benzyloxy-3-hydroxypentanoic acid [(S)-1-((S)-1-carbamoyl-3-methylbutylcarbamoyl)ethyl]amide

Base Information

Chemical Name:(3S,4S)-4-azido-5-benzyloxy-3-hydroxypentanoic acid [(S)-1-((S)-1-carbamoyl-3-methylbutylcarbamoyl)ethyl]amide
CAS No.:724733-53-3
Molecular Formula:C₂₁H₃₂N₆O₅
Molecular Weight:448.522
Hs Code.:

Synonyms:(3S,4S)-4-azido-5-benzyloxy-3-hydroxypentanoic acid [(S)-1-((S)-1-carbamoyl-3-methylbutylcarbamoyl)ethyl]amide

Suppliers and Price of (3S,4S)-4-azido-5-benzyloxy-3-hydroxypentanoic acid [(S)-1-((S)-1-carbamoyl-3-methylbutylcarbamoyl)ethyl]amide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (3S,4S)-4-azido-5-benzyloxy-3-hydroxypentanoic acid [(S)-1-((S)-1-carbamoyl-3-methylbutylcarbamoyl)ethyl]amide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (3S,4S)-4-azido-5-benzyloxy-3-hydroxypentanoic acid [(S)-1-((S)-1-carbamoyl-3-methylbutylcarbamoyl)ethyl]amide

There total 8 articles about (3S,4S)-4-azido-5-benzyloxy-3-hydroxypentanoic acid [(S)-1-((S)-1-carbamoyl-3-methylbutylcarbamoyl)ethyl]amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 38689-32-6
(S)-2-((S)-2-aminopropanoylamino)-4-methylpentanoic acid amide

: 724733-50-0
(3S,4S)-4-azido-5-benzyloxy-3-hydroxypentanoic acid

: 724733-53-3
(3S,4S)-4-azido-5-benzyloxy-3-hydroxypentanoic acid [(S)-1-((S)-1-carbamoyl-3-methylbutylcarbamoyl)ethyl]amide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 2h;
DOI:10.1021/jm031106i

Reference yield:

: 687-51-4,13079-20-4,13366-40-0,15893-47-7
H-L-Leu-NH₂

: 724733-53-3
(3S,4S)-4-azido-5-benzyloxy-3-hydroxypentanoic acid [(S)-1-((S)-1-carbamoyl-3-methylbutylcarbamoyl)ethyl]amide

Guidance literature:: Multi-step reaction with 3 steps

1: 1-hydroxy-7-azabenzotriazole; 1,8-bis(N,N-dimethylamino)naphthalene; N-(3-dimethylaminopropyl)-N'-ethylcarbodiimide hydrochloride / dimethylformamide / 0 - 20 °C

2: 100 percent / H₂ / Pd/C / aq. ethanol / 1.5 h / atmospheric pressure

3: 63 percent / diisopropylethylamine; HATU / dimethylformamide / 2 h / 0 - 20 °C

With 1-hydroxy-7-aza-benzotriazole; hydrogen; N,N,N',N'-tetramethyl-1,8-diaminonaphthalene; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; palladium on activated charcoal; In ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm031106i

Reference yield:

: 18323-56-3
Z-(S)-Ala-(S)-Leu-NH₂

: 724733-53-3
(3S,4S)-4-azido-5-benzyloxy-3-hydroxypentanoic acid [(S)-1-((S)-1-carbamoyl-3-methylbutylcarbamoyl)ethyl]amide

Guidance literature:: Multi-step reaction with 2 steps

1: 100 percent / H₂ / Pd/C / aq. ethanol / 1.5 h / atmospheric pressure

2: 63 percent / diisopropylethylamine; HATU / dimethylformamide / 2 h / 0 - 20 °C

With hydrogen; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; palladium on activated charcoal; In ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm031106i