Technology Process of (3S,4S)-4-azido-5-benzyloxy-3-hydroxypentanoic acid
There total 6 articles about (3S,4S)-4-azido-5-benzyloxy-3-hydroxypentanoic acid which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
(2S,3R,5S)-5-((S)-1-Azido-2-benzyloxy-ethyl)-tetrahydro-furan-2,3-diol;
With
sodium periodate;
In
tert-butyl alcohol;
at 20 ℃;
for 0.25h;
With
sodium periodate;
In
tert-butyl alcohol;
at 20 ℃;
for 0.25h;
With
sodium hydroxide;
In
1,4-dioxane;
at 20 ℃;
for 1h;
DOI:10.1021/jm031106i
- Guidance literature:
-
C13H17N3O4;
With
sodium periodate;
In
water; tert-butyl alcohol;
for 0.333333h;
With
potassium permanganate;
In
tetrahydrofuran; water;
for 1.5h;
With
sodium hydroxide;
In
water;
at 0 - 20 ℃;
Further stages;
DOI:10.1016/j.bmc.2008.09.041
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: triphenylphosphine; diisopropyl azodicarboxylate / tetrahydrofuran / 0.17 h / -15 °C
1.2: 100 percent / diphenylphosphoryl azide / tetrahydrofuran / 0 - 20 °C
2.1: aq. acetic acid / 1 h / Heating
3.1: aq. sodium periodate / 2-methyl-propan-2-ol / 0.25 h / 20 °C
3.2: aq. sodium periodate / 2-methyl-propan-2-ol / 0.25 h / 20 °C
3.3: 2.13 g / aq. sodium hydroxide / dioxane / 1 h / 20 °C
With
sodium periodate; di-isopropyl azodicarboxylate; acetic acid; triphenylphosphine;
In
tetrahydrofuran; tert-butyl alcohol;
DOI:10.1021/jm031106i
