17α-[(N-5-azido-2-nitro-3,4,6-trifluorophenyl)aminomethyl]-17β-hydroxy-5α-androstan-3-one

Base Information

Chemical Name:17α-[(N-5-azido-2-nitro-3,4,6-trifluorophenyl)aminomethyl]-17β-hydroxy-5α-androstan-3-one
CAS No.:300351-16-0
Molecular Formula:C₂₆H₃₂F₃N₅O₄
Molecular Weight:535.566
Hs Code.:

Synonyms:17α-[(N-5-azido-2-nitro-3,4,6-trifluorophenyl)aminomethyl]-17β-hydroxy-5α-androstan-3-one

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Chemical Property of 17α-[(N-5-azido-2-nitro-3,4,6-trifluorophenyl)aminomethyl]-17β-hydroxy-5α-androstan-3-one

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Technology Process of 17α-[(N-5-azido-2-nitro-3,4,6-trifluorophenyl)aminomethyl]-17β-hydroxy-5α-androstan-3-one

There total 5 articles about 17α-[(N-5-azido-2-nitro-3,4,6-trifluorophenyl)aminomethyl]-17β-hydroxy-5α-androstan-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 300351-15-9
17α-[(N-5-azido-2-nitro-3,4,6-trifluorophenyl)aminomethyl]-3,3-dimethoxy-5α-androstan-17β-ol

: 300351-16-0
17α-[(N-5-azido-2-nitro-3,4,6-trifluorophenyl)aminomethyl]-17β-hydroxy-5α-androstan-3-one

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; at 22 ℃; for 4h;
DOI:10.1016/S0039-128X(00)00106-9

Reference yield:

: 846-46-8
androstanedione

: 300351-16-0
17α-[(N-5-azido-2-nitro-3,4,6-trifluorophenyl)aminomethyl]-17β-hydroxy-5α-androstan-3-one

Guidance literature:: Multi-step reaction with 5 steps

1: 62 percent / pTsOH*H₂O / 1 h / 40 °C

2: 90 percent / potassium t-butoxide / dimethylformamide / 1 h / 22 °C

3: 72 percent / 25 percent aq. NH₄OH; AcOH / aq. ethanol / 72 h / 40 °C

4: 47 percent / Et₃N / tetrahydrofuran; ethanol; diethyl ether

5: 89 percent / aq. HCl / dioxane / 4 h / 22 °C

With hydrogenchloride; ammonium hydroxide; potassium tert-butylate; toluene-4-sulfonic acid; acetic acid; triethylamine; In tetrahydrofuran; 1,4-dioxane; diethyl ether; ethanol; N,N-dimethyl-formamide;
DOI:10.1016/S0039-128X(00)00106-9

Reference yield:

: 3591-19-3
3,3-(dimethoxy)-5α-androstan-17-one

: 300351-16-0
17α-[(N-5-azido-2-nitro-3,4,6-trifluorophenyl)aminomethyl]-17β-hydroxy-5α-androstan-3-one

Guidance literature:: Multi-step reaction with 4 steps

1: 90 percent / potassium t-butoxide / dimethylformamide / 1 h / 22 °C

2: 72 percent / 25 percent aq. NH₄OH; AcOH / aq. ethanol / 72 h / 40 °C

3: 47 percent / Et₃N / tetrahydrofuran; ethanol; diethyl ether

4: 89 percent / aq. HCl / dioxane / 4 h / 22 °C

With hydrogenchloride; ammonium hydroxide; potassium tert-butylate; acetic acid; triethylamine; In tetrahydrofuran; 1,4-dioxane; diethyl ether; ethanol; N,N-dimethyl-formamide;
DOI:10.1016/S0039-128X(00)00106-9