3591-19-3Relevant articles and documents
Method for synthesizing stanozolol intermediate androstane-17alpha-methyl-17beta-hydroxyl-3-ketone
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, (2019/04/09)
The invention provides a method for synthesizing a stanozolol intermediate androstane-17alpha-methyl-17beta-hydroxyl-3-ketone. The method comprises the following steps: taking 4-androstenedione as a raw material, carrying out 3-site and 17-site keto-double-ketal, 5-site ethylenic bond catalytic hydrogenation and 3-site and 17-site double-ketal hydrolysis to prepare a compound 5alpha-androstane-3,17-diketone; then carrying out 3-site keto-double-etherification and 17-site Grignard addition, and finally carrying out hydrolysis to prepare the compound androstane-17alpha-methyl-17beta-hydroxyl-3-ketone, wherein the HPLC (High Performance Liquid Chromatography) purity of the compound is 99.0% or greater. The method provided by the invention is short in route, easy in production process control,environmentally-friendly, low in production cost and applicable to industrial large-scale production.
Synthesis and substance P receptor binding activity of androstano[3,2- b]pyrimido[1,2-a]benzimidazoles
Venepalli,Aimone,Appell,Bell,Dority,Goswami,Hall,Kumar,Lawrence,Logan,Scensny,Seelye,Tomczuk,Yanni
, p. 374 - 378 (2007/10/02)
Several heterosteroids containing a dihydroethisterone skeleton were prepared and shown to displace substance P in a receptor binding assay. Further biochemical (kinetic and Scatchard analyses) and pharmacological evaluation (substance P-induced plasma extravasation and salivation in the rat) of a representative example in this series (5a) established that these compounds are competitive antagonists at the substance P receptor.
Synthesis of 17-hydroxyimino steroids and their O-alkyl derivatives.
Nagata,Sugasawa,Narisada,Okada,Sasakura,Murakami,Hayase
, p. 174 - 186 (2007/10/07)
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