methyl 4-<<5-<<(cyclopentyloxy)carbonyl>amino>benzothien-3-yl>methyl>-3-methoxybenzoate

Base Information

• Chemical Name: methyl 4-<<5-<<(cyclopentyloxy)carbonyl>amino>benzothien-3-yl>methyl>-3-methoxybenzoate
• CAS No.: 107786-72-1
• Molecular Formula: C₂₄H₂₅NO₅S
• Molecular Weight: 439.532

Synonyms:methyl 4-<<5-<<(cyclopentyloxy)carbonyl>amino>benzothien-3-yl>methyl>-3-methoxybenzoate

Chemical Property of methyl 4-<<5-<<(cyclopentyloxy)carbonyl>amino>benzothien-3-yl>methyl>-3-methoxybenzoate

Chemical Property:

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Technology Process of methyl 4-<<5-<<(cyclopentyloxy)carbonyl>amino>benzothien-3-yl>methyl>-3-methoxybenzoate

There total 7 articles about methyl 4-<<5-<<(cyclopentyloxy)carbonyl>amino>benzothien-3-yl>methyl>-3-methoxybenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

methyl 4-<(5-aminobenzothien-3-yl)methyl>-3-methoxybenzoate (107754-49-4) → methyl 4-<<5-<<(cyclopentyloxy)carbonyl>amino>benzothien-3-yl>methyl>-3-methoxybenzoate (107786-72-1)

Guidance literature:

Reference yield: 78.0%

cyclopentyl chloroformate (50715-28-1) + methyl 4-<(5-aminobenzothien-3-yl)methyl>-3-methoxybenzoate (107754-49-4) → methyl 4-<<5-<<(cyclopentyloxy)carbonyl>amino>benzothien-3-yl>methyl>-3-methoxybenzoate (107786-72-1)

Guidance literature:

With 2,6-dimethylpyridine; In dichloromethane; for 24h;

DOI:10.1021/jm00171a043

Reference yield:

methyl 5-nitrobenzo[b]thiophene-2-carboxylate (20699-86-9) → methyl 4-<<5-<<(cyclopentyloxy)carbonyl>amino>benzothien-3-yl>methyl>-3-methoxybenzoate (107786-72-1)

Guidance literature:

Multi-step reaction with 5 steps

1: aq. LiOH / tetrahydrofuran; methanol / 4 h

2: Cu⁰, quinoline / 170 - 180 °C

3: 30 percent / SnCl₄ / CH₂Cl₂ / 18 h / Heating

4: 54 percent / SnCl₂*2H₂O / ethanol / 2 h / Heating

5: 78 percent / 2,6-lutidine / CH₂Cl₂ / 24 h

With 2,6-dimethylpyridine; quinoline; lithium hydroxide; tin(IV) chloride; copper; tin(ll) chloride; In tetrahydrofuran; methanol; ethanol; dichloromethane;

DOI:10.1021/jm00171a043

upstream raw materials:

cyclopentyl chloroformate

methyl 4-<(5-aminobenzothien-3-yl)methyl>-3-methoxybenzoate

methyl 5-nitrobenzo[b]thiophene-2-carboxylate

5-nitrobenzo[b]thiophene

Downstream raw materials:

N-[4-[5-(cyclopentyloxycarbonyl)aminobenzo[b]thien-3-ylmethyl]-3-methoxybenzoyl]benzenesulphonamide

4-<<5-<<(cyclopentyloxy)carbonyl>amino>benzothien-3-yl>methyl>-3-methoxybenzoic acid

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