3-(4-chlorophenyl)-4,5-bis(4-fluorophenyl)-4,5-dihydro-1,2,4-oxadiazole

Base Information

Chemical Name:3-(4-chlorophenyl)-4,5-bis(4-fluorophenyl)-4,5-dihydro-1,2,4-oxadiazole
CAS No.:1419182-42-5
Molecular Formula:C₂₀H₁₃ClF₂N₂O
Molecular Weight:370.786
Hs Code.:

Synonyms:3-(4-chlorophenyl)-4,5-bis(4-fluorophenyl)-4,5-dihydro-1,2,4-oxadiazole

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3-(4-chlorophenyl)-4,5-bis(4-fluorophenyl)-4,5-dihydro-1,2,4-oxadiazole

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Technology Process of 3-(4-chlorophenyl)-4,5-bis(4-fluorophenyl)-4,5-dihydro-1,2,4-oxadiazole

There total 2 articles about 3-(4-chlorophenyl)-4,5-bis(4-fluorophenyl)-4,5-dihydro-1,2,4-oxadiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 39769-09-0
4-fluoro-N-[(1E/Z)-(4-fluorophenyl)methylene]aniline

: 28123-63-9
4-chlorobenzohydroximoyl chloride

: 1419182-42-5
3-(4-chlorophenyl)-4,5-bis(4-fluorophenyl)-4,5-dihydro-1,2,4-oxadiazole

Guidance literature:: With triethylamine; In diethyl ether; at 20 ℃;
DOI:10.1007/s00044-012-0436-9

Reference yield:

: 3848-36-0
4-chlorobenzaldoxime

: 1419182-42-5
3-(4-chlorophenyl)-4,5-bis(4-fluorophenyl)-4,5-dihydro-1,2,4-oxadiazole

Guidance literature:: Multi-step reaction with 2 steps

1: N-chloro-succinimide / N,N-dimethyl-formamide

2: triethylamine / diethyl ether / 20 °C

With N-chloro-succinimide; triethylamine; In diethyl ether; N,N-dimethyl-formamide;
DOI:10.1007/s00044-012-0436-9