2-(trimethylsilyl)ethyl-N-[(allyloxy)carbonyl]-L-norleucyl-(4R)-4-[(2-phenyl-6-vinylquinolin-4-yl)oxy]-L-prolinate

Base Information

Chemical Name:2-(trimethylsilyl)ethyl-N-[(allyloxy)carbonyl]-L-norleucyl-(4R)-4-[(2-phenyl-6-vinylquinolin-4-yl)oxy]-L-prolinate
CAS No.:914833-94-6
Molecular Formula:C₃₇H₄₇N₃O₆Si
Molecular Weight:657.882
Hs Code.:

Synonyms:2-(trimethylsilyl)ethyl-N-[(allyloxy)carbonyl]-L-norleucyl-(4R)-4-[(2-phenyl-6-vinylquinolin-4-yl)oxy]-L-prolinate

Suppliers and Price of 2-(trimethylsilyl)ethyl-N-[(allyloxy)carbonyl]-L-norleucyl-(4R)-4-[(2-phenyl-6-vinylquinolin-4-yl)oxy]-L-prolinate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 2-(trimethylsilyl)ethyl-N-[(allyloxy)carbonyl]-L-norleucyl-(4R)-4-[(2-phenyl-6-vinylquinolin-4-yl)oxy]-L-prolinate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 2-(trimethylsilyl)ethyl-N-[(allyloxy)carbonyl]-L-norleucyl-(4R)-4-[(2-phenyl-6-vinylquinolin-4-yl)oxy]-L-prolinate

There total 10 articles about 2-(trimethylsilyl)ethyl-N-[(allyloxy)carbonyl]-L-norleucyl-(4R)-4-[(2-phenyl-6-vinylquinolin-4-yl)oxy]-L-prolinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 783371-62-0
N-[(allyloxy)carbonyl]-L-norleucine

: C₂₇H₃₄N₂O₃Si

: 914833-94-6
2-(trimethylsilyl)ethyl-N-[(allyloxy)carbonyl]-L-norleucyl-(4R)-4-[(2-phenyl-6-vinylquinolin-4-yl)oxy]-L-prolinate

Guidance literature:: With 1-[bis(dimethylamino)methylen]-1-H-benzotriazolim-tetrafluoroborate-3-oxide; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 0.5h;

Reference yield:

: 112182-51-1
6-bromo-2-phenylquinolin-4(1H)-one

: 914833-94-6
2-(trimethylsilyl)ethyl-N-[(allyloxy)carbonyl]-L-norleucyl-(4R)-4-[(2-phenyl-6-vinylquinolin-4-yl)oxy]-L-prolinate

Guidance literature:: Multi-step reaction with 4 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / dimethyl sulfoxide / 20 h / 100 °C

2: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 54 h / 0 - 20 °C

3: hydrogenchloride / 1,4-dioxane / 1 h

4: 1-[bis(dimethylamino)methylen]-1-H-benzotriazolim-tetrafluoroborate-3-oxide; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.5 h / 20 °C

With hydrogenchloride; 1-[bis(dimethylamino)methylen]-1-H-benzotriazolim-tetrafluoroborate-3-oxide; N-ethyl-N,N-diisopropylamine; triphenylphosphine; diethylazodicarboxylate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; dimethyl sulfoxide; N,N-dimethyl-formamide; 2: Mitsunobu reaction;

Reference yield:

: 94-02-0
ethyl 3-oxo-3-phenylpropionate

: 914833-94-6
2-(trimethylsilyl)ethyl-N-[(allyloxy)carbonyl]-L-norleucyl-(4R)-4-[(2-phenyl-6-vinylquinolin-4-yl)oxy]-L-prolinate

Guidance literature:: Multi-step reaction with 5 steps

1.1: PPA / 3 h / 150 °C

1.2: 20 °C

2.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / dimethyl sulfoxide / 20 h / 100 °C

3.1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 54 h / 0 - 20 °C

4.1: hydrogenchloride / 1,4-dioxane / 1 h

5.1: 1-[bis(dimethylamino)methylen]-1-H-benzotriazolim-tetrafluoroborate-3-oxide; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.5 h / 20 °C

With hydrogenchloride; PPA; 1-[bis(dimethylamino)methylen]-1-H-benzotriazolim-tetrafluoroborate-3-oxide; N-ethyl-N,N-diisopropylamine; triphenylphosphine; diethylazodicarboxylate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; dimethyl sulfoxide; N,N-dimethyl-formamide; 3.1: Mitsunobu reaction;