2-(2-methoxy-4-(4-methylpiperazin-1-yl)phenylamino)-5-methyl-7a,8,9,10-tetrahydro-5H-pyrimido[5,4-b]pyrrolo[1,2-d][1,4]diazepin-6(7H)-one

Base Information

Chemical Name:2-(2-methoxy-4-(4-methylpiperazin-1-yl)phenylamino)-5-methyl-7a,8,9,10-tetrahydro-5H-pyrimido[5,4-b]pyrrolo[1,2-d][1,4]diazepin-6(7H)-one
CAS No.:1234479-69-6
Molecular Formula:C₂₃H₃₁N₇O₂
Molecular Weight:437.545
Hs Code.:

Synonyms:2-(2-methoxy-4-(4-methylpiperazin-1-yl)phenylamino)-5-methyl-7a,8,9,10-tetrahydro-5H-pyrimido[5,4-b]pyrrolo[1,2-d][1,4]diazepin-6(7H)-one

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Chemical Property of 2-(2-methoxy-4-(4-methylpiperazin-1-yl)phenylamino)-5-methyl-7a,8,9,10-tetrahydro-5H-pyrimido[5,4-b]pyrrolo[1,2-d][1,4]diazepin-6(7H)-one

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Technology Process of 2-(2-methoxy-4-(4-methylpiperazin-1-yl)phenylamino)-5-methyl-7a,8,9,10-tetrahydro-5H-pyrimido[5,4-b]pyrrolo[1,2-d][1,4]diazepin-6(7H)-one

There total 4 articles about 2-(2-methoxy-4-(4-methylpiperazin-1-yl)phenylamino)-5-methyl-7a,8,9,10-tetrahydro-5H-pyrimido[5,4-b]pyrrolo[1,2-d][1,4]diazepin-6(7H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 122833-04-9
2-methoxy-4-(4-methylpiperazin-1-yl)aniline

: 1234479-68-5
C₁₁H₁₃ClN₄O

: 1234479-69-6
2-(2-methoxy-4-(4-methylpiperazin-1-yl)phenylamino)-5-methyl-7a,8,9,10-tetrahydro-5H-pyrimido[5,4-b]pyrrolo[1,2-d][1,4]diazepin-6(7H)-one

Guidance literature:: With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; potassium carbonate; XPhos; In tert-butyl alcohol; at 100 ℃;
DOI:10.1021/ml100304b

Reference yield:

: 1234479-66-3
C₁₁H₁₃ClN₄O₄

: 1234479-69-6
2-(2-methoxy-4-(4-methylpiperazin-1-yl)phenylamino)-5-methyl-7a,8,9,10-tetrahydro-5H-pyrimido[5,4-b]pyrrolo[1,2-d][1,4]diazepin-6(7H)-one

Guidance literature:: Multi-step reaction with 3 steps

1: iron; acetic acid / 50 °C

2: sodium hydride / N,N-dimethyl acetamide / 0 °C

3: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; potassium carbonate; XPhos / tert-butyl alcohol / 100 °C

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; iron; sodium hydride; potassium carbonate; acetic acid; XPhos; In N,N-dimethyl acetamide; tert-butyl alcohol;
DOI:10.1021/ml100304b

Reference yield:

: 259868-83-2
(S)-pyrrolidin-2-ylacetic acid methyl ester hydrochloride

: 1234479-69-6
2-(2-methoxy-4-(4-methylpiperazin-1-yl)phenylamino)-5-methyl-7a,8,9,10-tetrahydro-5H-pyrimido[5,4-b]pyrrolo[1,2-d][1,4]diazepin-6(7H)-one

Guidance literature:: Multi-step reaction with 4 steps

1: N-ethyl-N,N-diisopropylamine / isopropyl alcohol / 20 °C

2: iron; acetic acid / 50 °C

3: sodium hydride / N,N-dimethyl acetamide / 0 °C

4: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; potassium carbonate; XPhos / tert-butyl alcohol / 100 °C

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; iron; sodium hydride; potassium carbonate; acetic acid; N-ethyl-N,N-diisopropylamine; XPhos; In N,N-dimethyl acetamide; isopropyl alcohol; tert-butyl alcohol;
DOI:10.1021/ml100304b