methyl (Z)-2-bromo-3-[1-(2,4,6-trimethylphenylsulfonyl)-1H-pyrrol-2-yl]prop-2-enoate

Base Information

• Chemical Name: methyl (Z)-2-bromo-3-[1-(2,4,6-trimethylphenylsulfonyl)-1H-pyrrol-2-yl]prop-2-enoate
• CAS No.: 1342341-38-1
• Molecular Formula: C₁₇H₁₈BrNO₄S
• Molecular Weight: 412.304

Synonyms:methyl (Z)-2-bromo-3-[1-(2,4,6-trimethylphenylsulfonyl)-1H-pyrrol-2-yl]prop-2-enoate

Chemical Property of methyl (Z)-2-bromo-3-[1-(2,4,6-trimethylphenylsulfonyl)-1H-pyrrol-2-yl]prop-2-enoate

Chemical Property:

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Technology Process of methyl (Z)-2-bromo-3-[1-(2,4,6-trimethylphenylsulfonyl)-1H-pyrrol-2-yl]prop-2-enoate

There total 2 articles about methyl (Z)-2-bromo-3-[1-(2,4,6-trimethylphenylsulfonyl)-1H-pyrrol-2-yl]prop-2-enoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

2-mesitylenesulphonyl chloride (773-64-8) + methyl (Z)-2-bromo-3-(1H-pyrrol-2-yl)prop-2-enoate (1342341-35-8) → methyl (Z)-2-bromo-3-[1-(2,4,6-trimethylphenylsulfonyl)-1H-pyrrol-2-yl]prop-2-enoate (1342341-38-1)

Guidance literature:

methyl (Z)-2-bromo-3-(1H-pyrrol-2-yl)prop-2-enoate; With sodium hydride; In tetrahydrofuran; mineral oil; Cooling;

2-mesitylenesulphonyl chloride; In tetrahydrofuran; mineral oil; for 0.5h; Cooling;

DOI:10.1055/s-0030-1260098

Reference yield:

2-pyrrole aldehyde (1003-29-8,254729-95-8) → methyl (Z)-2-bromo-3-[1-(2,4,6-trimethylphenylsulfonyl)-1H-pyrrol-2-yl]prop-2-enoate (1342341-38-1)

Guidance literature:

Multi-step reaction with 2 steps

1.1: chloroform / 12 h / Reflux

2.1: sodium hydride / tetrahydrofuran; mineral oil / Cooling

2.2: 0.5 h / Cooling

With sodium hydride; In tetrahydrofuran; chloroform; mineral oil;

DOI:10.1055/s-0030-1260098

Reference yield: 100.0%

methyl (Z)-2-bromo-3-[1-(2,4,6-trimethylphenylsulfonyl)-1H-pyrrol-2-yl]prop-2-enoate (1342341-38-1) → (Z)-2-bromo-3-[1-(2,4,6-trimethylphenylsulfonyl)-1H-pyrrol-2-yl]prop-2-en-1-ol (1342341-39-2)

Guidance literature:

With diisobutylaluminium hydride; In tetrahydrofuran; hexane; for 3h; Cooling;

DOI:10.1055/s-0030-1260098

upstream raw materials:

2-pyrrole aldehyde

2-mesitylenesulphonyl chloride

methyl (Z)-2-bromo-3-(1H-pyrrol-2-yl)prop-2-enoate

Downstream raw materials:

(Z)-2-bromo-3-[1-(2,4,6-trimethylphenylsulfonyl)-1H-pyrrol-2-yl]prop-2-en-1-ol

N-{(Z)-2-bromo-3-[1-(2,4,6-trimethylphenylsulfonyl)-1H-pyrrol-2-yl]prop-2-enyl}-N-[(1R)-1-cyclohexylhept-2-ynyl]-4-methylbenzenesulfonamide

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