(4R)-hydroxy-(2S)-N-[4-(3-bromopropoxy)-5-methoxy-2-nitrobenzoyl]-pyrrolidine-2-carboxaldehyde diethyl thioacetal

Base Information

Chemical Name:(4R)-hydroxy-(2S)-N-[4-(3-bromopropoxy)-5-methoxy-2-nitrobenzoyl]-pyrrolidine-2-carboxaldehyde diethyl thioacetal
CAS No.:625123-59-3
Molecular Formula:C₂₀H₂₉BrN₂O₆S₂
Molecular Weight:537.496
Hs Code.:

Synonyms:(4R)-hydroxy-(2S)-N-[4-(3-bromopropoxy)-5-methoxy-2-nitrobenzoyl]-pyrrolidine-2-carboxaldehyde diethyl thioacetal

Suppliers and Price of (4R)-hydroxy-(2S)-N-[4-(3-bromopropoxy)-5-methoxy-2-nitrobenzoyl]-pyrrolidine-2-carboxaldehyde diethyl thioacetal

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (4R)-hydroxy-(2S)-N-[4-(3-bromopropoxy)-5-methoxy-2-nitrobenzoyl]-pyrrolidine-2-carboxaldehyde diethyl thioacetal

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (4R)-hydroxy-(2S)-N-[4-(3-bromopropoxy)-5-methoxy-2-nitrobenzoyl]-pyrrolidine-2-carboxaldehyde diethyl thioacetal

There total 3 articles about (4R)-hydroxy-(2S)-N-[4-(3-bromopropoxy)-5-methoxy-2-nitrobenzoyl]-pyrrolidine-2-carboxaldehyde diethyl thioacetal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 75-08-1
ethanethiol

: 625123-58-2
(2S,4R)-1-[4-(3-Bromo-propoxy)-5-methoxy-2-nitro-benzoyl]-4-(tert-butyl-dimethyl-silanyloxy)-pyrrolidine-2-carbaldehyde

: 625123-59-3
(4R)-hydroxy-(2S)-N-[4-(3-bromopropoxy)-5-methoxy-2-nitrobenzoyl]-pyrrolidine-2-carboxaldehyde diethyl thioacetal

Guidance literature:: With chloro-trimethyl-silane; In chloroform; at 20 ℃; for 18h;
DOI:10.1016/S0960-894X(03)00718-2

Reference yield:

: (2S,4R)-1-[4-(3-Bromo-propoxy)-5-methoxy-2-nitro-benzoyl]-4-hydroxy-pyrrolidine-2-carboxylic acid methyl ester

: 625123-59-3
(4R)-hydroxy-(2S)-N-[4-(3-bromopropoxy)-5-methoxy-2-nitrobenzoyl]-pyrrolidine-2-carboxaldehyde diethyl thioacetal

Guidance literature:: Multi-step reaction with 3 steps

1: 88 percent / imidazole / CH₂Cl₂ / 12 h / 20 °C

2: 68 percent / DIBAL-H / CH₂Cl₂ / 1 h / -78 °C

3: 85 percent / TMS-Cl / CHCl₃ / 18 h / 20 °C

With 1H-imidazole; chloro-trimethyl-silane; diisobutylaluminium hydride; In dichloromethane; chloroform;
DOI:10.1016/S0960-894X(03)00718-2

Reference yield:

: 625123-57-1
(2S,4R)-1-[4-(3-Bromo-propoxy)-5-methoxy-2-nitro-benzoyl]-4-(tert-butyl-dimethyl-silanyloxy)-pyrrolidine-2-carboxylic acid methyl ester

: 625123-59-3
(4R)-hydroxy-(2S)-N-[4-(3-bromopropoxy)-5-methoxy-2-nitrobenzoyl]-pyrrolidine-2-carboxaldehyde diethyl thioacetal

Guidance literature:: Multi-step reaction with 2 steps

1: 68 percent / DIBAL-H / CH₂Cl₂ / 1 h / -78 °C

2: 85 percent / TMS-Cl / CHCl₃ / 18 h / 20 °C

With chloro-trimethyl-silane; diisobutylaluminium hydride; In dichloromethane; chloroform;
DOI:10.1016/S0960-894X(03)00718-2