4-(dimethylamino)-2-fluorobenzaldehyde

Base Information

• Chemical Name: 4-(dimethylamino)-2-fluorobenzaldehyde
• CAS No.: 1524-07-8
• Molecular Formula: C9H10 F N O
• Molecular Weight: 167.183
• Mol file: 1524-07-8.mol

Synonyms:NSC 151869

Chemical Property of 4-(dimethylamino)-2-fluorobenzaldehyde

Chemical Property:

• Vapor Pressure: 0.00449mmHg at 25°C
• Boiling Point: 277.6°C at 760 mmHg
• Flash Point: 121.7°C
• Density: 1.166g/cm³

Purity/Quality:

98%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-(dimethylamino)-2-fluorobenzaldehyde

There total 2 articles about 4-(dimethylamino)-2-fluorobenzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N,N-dimethyl 3-fluoroaniline (2107-43-9) + N,N-dimethyl-formamide (68-12-2,33513-42-7) → 2-fluoro-4-(dimethylamino)benzaldehyde (1524-07-8)

Guidance literature:

With water; trichlorophosphate; Yield given. Multistep reaction;

DOI:10.1021/jm00378a030

Reference yield:

→ 2-fluoro-4-(dimethylamino)benzaldehyde (1524-07-8)

Guidance literature:

N,N-Dimethyl-3-fluor-anilin, analog Campaigne, Archer (Org. Synth. 33 (1953) 27);

DOI:10.1021/jo01081a616

Reference yield: 75.0%

2,6-dichloro-p-phenylenediamine (609-20-1) + 2-fluoro-4-(dimethylamino)benzaldehyde (1524-07-8) → 2,6-Dichloro-N'-[1-(4-dimethylamino-2-fluoro-phenyl)-meth-(E)-ylidene]-benzene-1,4-diamine (84562-66-3)

Guidance literature:

In ethanol; for 1.5h; Heating;

DOI:10.1021/jm00378a030

upstream raw materials:

N,N-dimethyl 3-fluoroaniline

N,N-dimethyl-formamide

Downstream raw materials:

2,6-Dichloro-N'-[1-(4-dimethylamino-2-fluoro-phenyl)-meth-(E)-ylidene]-benzene-1,4-diamine

2,6-Dichloro-N'-(4-dimethylamino-2-fluoro-benzyl)-benzene-1,4-diamine

N'-[2,6-Dichloro-4-(4-dimethylamino-2-fluoro-benzylamino)-phenyl]-N,N-dimethyl-formamidine

4-dimethylamino-2-fluoro-1-(5'-(5''-(4'''-methylpiperazin-1'''-yl)benzimidazol-2''-yl)benzimidazol-2'-yl)benzene