2107-43-9

Basic information

• Product Name: N,N-DIMETHYL-3-FLUOROANILINE
• Synonyms: 1-(DIMETHYLAMINO)-3-FLUOROBENZENE;N,N-DIMETHYL-3-FLUOROANILINE;1-Fluoro-3-(dimethylamino)benzene;3-Fluoro-N,N-diMethylaniline
• CAS NO: 2107-43-9
• Molecular Formula: C₈H₁₀FN
• Molecular Weight: 139.17
• Mol File: 2107-43-9.mol
• Article Data: 15

Chemical Properties

• Boiling Point: 219.8°C at 760 mmHg
• Flash Point: 99.5°C
• Appearance: /
• Density: 1.083g/cm³
• Vapor Pressure: 0.117mmHg at 25°C
• Refractive Index: 1.537
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: N,N-DIMETHYL-3-FLUOROANILINE(CAS DataBase Reference)
• NIST Chemistry Reference: N,N-DIMETHYL-3-FLUOROANILINE(2107-43-9)
• EPA Substance Registry System: N,N-DIMETHYL-3-FLUOROANILINE(2107-43-9)

Safety Data

• Hazard Codes: Xi
• Statements: 20/21/22-36/37/38
• Safety Statements: 26-36/37/39
• RIDADR: 1993
• HazardClass: 3
• PackingGroup: Ⅲ
• Hazardous Substances Data: 2107-43-9(Hazardous Substances Data)

Usage

General Description

N,N-Dimethyl-3-fluoroaniline is a chemical compound with the molecular formula C8H10FN. It is a pale yellow liquid at room temperature and is primarily used as an intermediate in the production of pharmaceuticals, dyes, and agrochemicals. This chemical is known for its strong odor and is classified as a hazardous substance. N,N-Dimethyl-3-fluoroaniline is toxic if ingested, inhaled, or absorbed through the skin, and can cause irritation to the eyes and skin. It is important to handle this chemical with caution and follow proper safety protocols when working with it.

InChI:InChI=1/C8H10FN/c1-5-3-4-7(10)6(2)8(5)9/h3-4H,10H2,1-2H3

Upstream product

• 512-56-1 trimethyl phosphite 
• 372-19-0 meta-fluoroaniline 
• 365427-36-7 3-(dimethylamino)phenyl trifluoromethanesulfonate 
• 67-56-1 methanol 
• 50-00-0 formaldehyd 
• 16518-62-0 3-bromo-N,N-dimethylaniline 
• 124-38-9 carbon dioxide 
• 1978-37-6 3-fluoro-N-methylaniline 
• 99-07-0 3-Dimethylaminophenol 
• 77-78-1 dimethyl sulfate 
• 124-41-4 sodium methylate 
• 454-60-4 3-fluoro-tri-N-methyl-anilinium; iodide 

Downstream Products

• 98125-61-2 C₂₀H₁₈F₂N₂O₂ 
• 403-22-5 3-fluoro-N,N-dimethyl-4-nitro-aniline 
• 455-92-5 3-fluoro-N,N-dimethyl-4-nitroso-aniline 
• 334905-81-6 2-Fluoro-N⁴,N⁴-dimethyl-benzene-1,4-diamine 
• 1129542-03-5 3-fluoro-N,N-dimethyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)aniline 
• 1289194-73-5 2-(dimethylamino)-6-fluorobenzaldehyde 
• 14703-83-4 5-(dimethylamino)-2-nitrophenol 
• 85103-78-2 N'-[2,6-Dichloro-4-(4-dimethylamino-2-fluoro-benzylamino)-phenyl]-N,N-dimethyl-formamidine 
• 85103-79-3 2,6-Dichloro-N'-(4-dimethylamino-2-fluoro-benzyl)-benzene-1,4-diamine 
• 84562-66-3 2,6-Dichloro-N'-[1-(4-dimethylamino-2-fluoro-phenyl)-meth-(E)-ylidene]-benzene-1,4-diamine 

Relevant articles and documents

Additive-freeN-methylation of amines with methanol over supported iridium catalyst

An efficient and versatile zinc oxide-supported iridium (Ir/ZnO) catalyst was developed to catalyze the additive-freeN-methylation of amines with methanol. Mechanistic studies suggested that the high catalytic reactivity is rooted in the small sizes (1.4 nm) of Ir nanoparticles and the high ratio (93%) of oxidized iridium species (IrOx, Ir3+and Ir4+) on the catalyst. Moreover, the delicate cooperation between the IrOxand ZnO support also promoted its high reactivity. The selectivity of this catalyticN-methylation was controllable between dimethylation and monomethylation by carefully tuning the catalyst loading and reaction solvent. Specifically, neat methanol with high catalyst loading (2 mol% Ir) favored the formation ofN,N-dimethylated amine, while the mesitylene/methanol mixture with low catalyst loading (0.5 mol% Ir) was prone to producing mono-N-methylated amines. An environmentally benign continuous flow system with a recycled mode was also developed for the efficient production ofN-methylated amines. With optimal flow rates and amine concentrations, a variety ofN-methylamines were produced with good to excellent yields in this Ir/ZnO-based flow system, providing a starting point for the clean and efficient production ofN-methylamines with this cost-effective chemical process.

Para-Selective C-H Olefination of Aniline Derivatives via Pd/S,O-Ligand Catalysis

Herein we report a highly para-selective C-H olefination of aniline derivatives by a Pd/S,O-ligand-based catalyst. The reaction proceeds under mild reaction conditions with high efficiency and broad substrate scope, including mono-, di-, and trisubstituted tertiary, secondary, and primary anilines. The S,O-ligand is responsible for the dramatic improvements in substrate scope and the high para-selectivity observed. This methodology is operationally simple, scalable, and can be performed under aerobic conditions.

Method for the methylation of nitrogen-containing Organic Compounds

A method for the methylation of amines, amides and imines comprises the step of reacting these compounds with CO2 and H2 in the presence of a Ruthenium-phosphine complex.