7-((4-(4-fluorophenyl)pyridin-2-yl)(1-methyl-1H-pyrazol-3-yl)amino)-N-hydroxyheptanamide

Base Information

Chemical Name:7-((4-(4-fluorophenyl)pyridin-2-yl)(1-methyl-1H-pyrazol-3-yl)amino)-N-hydroxyheptanamide
CAS No.:1609524-52-8
Molecular Formula:C₂₂H₂₆FN₅O₂
Molecular Weight:411.479
Hs Code.:

Synonyms:7-((4-(4-fluorophenyl)pyridin-2-yl)(1-methyl-1H-pyrazol-3-yl)amino)-N-hydroxyheptanamide

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Chemical Property of 7-((4-(4-fluorophenyl)pyridin-2-yl)(1-methyl-1H-pyrazol-3-yl)amino)-N-hydroxyheptanamide

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Technology Process of 7-((4-(4-fluorophenyl)pyridin-2-yl)(1-methyl-1H-pyrazol-3-yl)amino)-N-hydroxyheptanamide

There total 4 articles about 7-((4-(4-fluorophenyl)pyridin-2-yl)(1-methyl-1H-pyrazol-3-yl)amino)-N-hydroxyheptanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 10.0%

: 1609524-54-0
ethyl 7-((4-(4-fluorophenyl)pyridin-2-yl)(1-methyl-1H-pyrazol-3-yl)amino)heptanoate

: 1609524-52-8
7-((4-(4-fluorophenyl)pyridin-2-yl)(1-methyl-1H-pyrazol-3-yl)amino)-N-hydroxyheptanamide

Guidance literature:: With hydroxylamine; potassium hydroxide; In methanol; at 20 ℃; for 21h;

Reference yield:

: 29823-18-5
ethyl 7-bromoheptanoate

: 1609524-52-8
7-((4-(4-fluorophenyl)pyridin-2-yl)(1-methyl-1H-pyrazol-3-yl)amino)-N-hydroxyheptanamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium iodide / acetone / 18 h / 60 °C

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.33 h / 5 °C / Inert atmosphere

2.2: 1 h / 70 °C / Inert atmosphere; Darkness

3.1: hydroxylamine; potassium hydroxide / methanol / 21 h / 20 °C

With hydroxylamine; sodium hydride; sodium iodide; potassium hydroxide; In methanol; N,N-dimethyl-formamide; acetone; mineral oil;

Reference yield:

: 883874-84-8
2-chloro-4-(4-fluorophenyl)pyridine

: 1609524-52-8
7-((4-(4-fluorophenyl)pyridin-2-yl)(1-methyl-1H-pyrazol-3-yl)amino)-N-hydroxyheptanamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane / 0.17 h / Inert atmosphere

1.2: 30 h / 90 °C

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.33 h / 5 °C / Inert atmosphere

2.2: 1 h / 70 °C / Inert atmosphere; Darkness

3.1: hydroxylamine; potassium hydroxide / methanol / 21 h / 20 °C

With hydroxylamine; sodium hydride; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; potassium hydroxide; In 1,4-dioxane; methanol; N,N-dimethyl-formamide; mineral oil;