ethyl 7-((4-(4-fluorophenyl)pyridin-2-yl)(1-methyl-1H-pyrazol-3-yl)amino)heptanoate

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Chemical Name:ethyl 7-((4-(4-fluorophenyl)pyridin-2-yl)(1-methyl-1H-pyrazol-3-yl)amino)heptanoate
CAS No.:1609524-54-0
Molecular Formula:C₂₄H₂₉FN₄O₂
Molecular Weight:424.518
Hs Code.:

Synonyms:ethyl 7-((4-(4-fluorophenyl)pyridin-2-yl)(1-methyl-1H-pyrazol-3-yl)amino)heptanoate

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Chemical Property of ethyl 7-((4-(4-fluorophenyl)pyridin-2-yl)(1-methyl-1H-pyrazol-3-yl)amino)heptanoate

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Technology Process of ethyl 7-((4-(4-fluorophenyl)pyridin-2-yl)(1-methyl-1H-pyrazol-3-yl)amino)heptanoate

There total 3 articles about ethyl 7-((4-(4-fluorophenyl)pyridin-2-yl)(1-methyl-1H-pyrazol-3-yl)amino)heptanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 51100-70-0
ethyl 7-iodoheptanoate

: 1609524-53-9
4-(4-fluorophenyl)-N-(1-methyl-1H-pyrazol-3-yl)pyridin-2-amine

: 1609524-54-0
ethyl 7-((4-(4-fluorophenyl)pyridin-2-yl)(1-methyl-1H-pyrazol-3-yl)amino)heptanoate

Guidance literature:: 4-(4-fluorophenyl)-N-(1-methyl-1H-pyrazol-3-yl)pyridin-2-amine; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 5 ℃; for 0.333333h; Inert atmosphere;

ethyl 7-iodoheptanoate; In N,N-dimethyl-formamide; mineral oil; at 70 ℃; for 1h; Inert atmosphere; Darkness;

Reference yield:

: 29823-18-5
ethyl 7-bromoheptanoate

: 1609524-54-0
ethyl 7-((4-(4-fluorophenyl)pyridin-2-yl)(1-methyl-1H-pyrazol-3-yl)amino)heptanoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium iodide / acetone / 18 h / 60 °C

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.33 h / 5 °C / Inert atmosphere

2.2: 1 h / 70 °C / Inert atmosphere; Darkness

With sodium hydride; sodium iodide; In N,N-dimethyl-formamide; acetone; mineral oil;

Reference yield:

: 883874-84-8
2-chloro-4-(4-fluorophenyl)pyridine

: 1609524-54-0
ethyl 7-((4-(4-fluorophenyl)pyridin-2-yl)(1-methyl-1H-pyrazol-3-yl)amino)heptanoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane / 0.17 h / Inert atmosphere

1.2: 30 h / 90 °C

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.33 h / 5 °C / Inert atmosphere

2.2: 1 h / 70 °C / Inert atmosphere; Darkness

With sodium hydride; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; N,N-dimethyl-formamide; mineral oil;