N₁,N₃-dibutyl-4,6-bis[4-((triisopropylsilyl)ethynyl)phenyl]-isophthalamide

Base Information

Chemical Name:N₁,N₃-dibutyl-4,6-bis[4-((triisopropylsilyl)ethynyl)phenyl]-isophthalamide
CAS No.:1356125-88-6
Molecular Formula:C₅₄H₇₂N₂O₂Si₂
Molecular Weight:837.349
Hs Code.:

N<sub>1</sub>,N<sub>3</sub>-dibutyl-4,6-bis[4-((triisopropylsilyl)ethynyl)phenyl]-isophthalamide

Synonyms:N₁,N₃-dibutyl-4,6-bis[4-((triisopropylsilyl)ethynyl)phenyl]-isophthalamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N₁,N₃-dibutyl-4,6-bis[4-((triisopropylsilyl)ethynyl)phenyl]-isophthalamide

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Technology Process of N₁,N₃-dibutyl-4,6-bis[4-((triisopropylsilyl)ethynyl)phenyl]-isophthalamide

There total 3 articles about N₁,N₃-dibutyl-4,6-bis[4-((triisopropylsilyl)ethynyl)phenyl]-isophthalamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

: 1356125-47-7
N₁,N₃-dibutyl-4,6-dibromoisophthalamide

: 175345-90-1
1-((triisopropylsilyl)ethynyl)-4-ethynylbenzene

: 1356125-88-6
N₁,N₃-dibutyl-4,6-bis[4-((triisopropylsilyl)ethynyl)phenyl]-isophthalamide

Guidance literature:: With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine; In tetrahydrofuran; at 70 ℃; Inert atmosphere;
DOI:10.1021/jo2021345

Reference yield:

: 24063-27-2
4,6-dibromobenzene-1,3-dicarboxylic acid

: 1356125-88-6
N₁,N₃-dibutyl-4,6-bis[4-((triisopropylsilyl)ethynyl)phenyl]-isophthalamide

Guidance literature:: Multi-step reaction with 3 steps

1: thionyl chloride / benzene / 5 h / Reflux

2: pyridine / dichloromethane / 18 h / 20 °C

3: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; triethylamine / tetrahydrofuran / 70 °C / Inert atmosphere

With pyridine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; thionyl chloride; triethylamine; In tetrahydrofuran; dichloromethane; benzene; 3: Sonogashira coupling;
DOI:10.1021/jo2021345

Reference yield:

: 91997-32-9
4,6-dibromobenzene-1,3-dicarboxylic acid dichloride

: 1356125-88-6
N₁,N₃-dibutyl-4,6-bis[4-((triisopropylsilyl)ethynyl)phenyl]-isophthalamide

Guidance literature:: Multi-step reaction with 2 steps

1: pyridine / dichloromethane / 18 h / 20 °C

2: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; triethylamine / tetrahydrofuran / 70 °C / Inert atmosphere

With pyridine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine; In tetrahydrofuran; dichloromethane; 2: Sonogashira coupling;
DOI:10.1021/jo2021345