methyl 2-((aminocarbonyl){(E)-3-[3-({5-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-oxazol-4-yl}methoxy)phenyl]2-butenyl}amino)acetate

Base Information

Chemical Name:methyl 2-((aminocarbonyl){(E)-3-[3-({5-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-oxazol-4-yl}methoxy)phenyl]2-butenyl}amino)acetate
CAS No.:263567-49-3
Molecular Formula:C₂₆H₂₆F₃N₃O₅
Molecular Weight:517.505
Hs Code.:

Synonyms:methyl 2-((aminocarbonyl){(E)-3-[3-({5-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-oxazol-4-yl}methoxy)phenyl]2-butenyl}amino)acetate

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Chemical Property of methyl 2-((aminocarbonyl){(E)-3-[3-({5-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-oxazol-4-yl}methoxy)phenyl]2-butenyl}amino)acetate

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Technology Process of methyl 2-((aminocarbonyl){(E)-3-[3-({5-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-oxazol-4-yl}methoxy)phenyl]2-butenyl}amino)acetate

There total 8 articles about methyl 2-((aminocarbonyl){(E)-3-[3-({5-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-oxazol-4-yl}methoxy)phenyl]2-butenyl}amino)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

: 590-28-3
potassium cyanate

: ((E)-3-{3-[5-Methyl-2-(4-trifluoromethyl-phenyl)-oxazol-4-ylmethoxy]-phenyl}-but-2-enylamino)-acetic acid methyl ester

: 263567-49-3
methyl 2-((aminocarbonyl){(E)-3-[3-({5-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-oxazol-4-yl}methoxy)phenyl]2-butenyl}amino)acetate

Guidance literature:: With acetic acid; at 40 ℃; for 0.333333h;
DOI:10.1021/jm990476x

Reference yield:

: 455-19-6
4-Trifluoromethylbenzaldehyde

: 263567-49-3
methyl 2-((aminocarbonyl){(E)-3-[3-({5-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-oxazol-4-yl}methoxy)phenyl]2-butenyl}amino)acetate

Guidance literature:: Multi-step reaction with 8 steps

1.1: 65 percent / HCl gas / ethyl acetate / 3 h / 5 °C

2.1: 30 percent / POCl₃ / CHCl₃ / 2.5 h / Heating

3.1: 82 percent / K₂CO₃ / dimethylformamide / 10 h / 65 °C

4.1: NaH / toluene / 1 h

4.2: 81 percent / toluene; tetrahydrofuran / 48 h

5.1: 95 percent / DIBAL / diethyl ether / 0.5 h / -78 °C

6.1: 35 percent / PCl₅; CaCO₃ / diethyl ether / 0.5 h / 0 °C

7.1: 2.0 g / Et₃N / tetrahydrofuran / 18 h / Heating

8.1: 51 percent / aq. AcOH / 0.33 h / 40 °C

With hydrogenchloride; phosphorus pentachloride; sodium hydride; diisobutylaluminium hydride; potassium carbonate; acetic acid; triethylamine; calcium carbonate; trichlorophosphate; In tetrahydrofuran; diethyl ether; chloroform; ethyl acetate; N,N-dimethyl-formamide; toluene; 1.1: Condensation / 2.1: Chlorination / 3.1: Alkylation / 4.1: Metallation / 4.2: Condensation / 5.1: Reduction / 6.1: Chlorination / 7.1: Condensation / 8.1: Condensation;
DOI:10.1021/jm990476x

Reference yield:

: 174258-39-0
4-(chloromethyl)-5-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-oxazole

: 263567-49-3
methyl 2-((aminocarbonyl){(E)-3-[3-({5-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-oxazol-4-yl}methoxy)phenyl]2-butenyl}amino)acetate

Guidance literature:: Multi-step reaction with 6 steps

1.1: 82 percent / K₂CO₃ / dimethylformamide / 10 h / 65 °C

2.1: NaH / toluene / 1 h

2.2: 81 percent / toluene; tetrahydrofuran / 48 h

3.1: 95 percent / DIBAL / diethyl ether / 0.5 h / -78 °C

4.1: 35 percent / PCl₅; CaCO₃ / diethyl ether / 0.5 h / 0 °C

5.1: 2.0 g / Et₃N / tetrahydrofuran / 18 h / Heating

6.1: 51 percent / aq. AcOH / 0.33 h / 40 °C

With phosphorus pentachloride; sodium hydride; diisobutylaluminium hydride; potassium carbonate; acetic acid; triethylamine; calcium carbonate; In tetrahydrofuran; diethyl ether; N,N-dimethyl-formamide; toluene; 1.1: Alkylation / 2.1: Metallation / 2.2: Condensation / 3.1: Reduction / 4.1: Chlorination / 5.1: Condensation / 6.1: Condensation;
DOI:10.1021/jm990476x