[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-isopropyl-carbamic acid 5-benzyloxy-3,3-difluoro-4-hydroxy-2-oxo-pentyl ester

Base Information

Chemical Name:[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-isopropyl-carbamic acid 5-benzyloxy-3,3-difluoro-4-hydroxy-2-oxo-pentyl ester
CAS No.:255715-06-1
Molecular Formula:C₃₄H₄₃F₂NO₆Si
Molecular Weight:627.801
Hs Code.:

[2-(<i>tert</i>-butyl-diphenyl-silanyloxy)-ethyl]-isopropyl-carbamic acid 5-benzyloxy-3,3-difluoro-4-hydroxy-2-oxo-pentyl ester

Synonyms:[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-isopropyl-carbamic acid 5-benzyloxy-3,3-difluoro-4-hydroxy-2-oxo-pentyl ester

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Chemical Property of [2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-isopropyl-carbamic acid 5-benzyloxy-3,3-difluoro-4-hydroxy-2-oxo-pentyl ester

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Technology Process of [2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-isopropyl-carbamic acid 5-benzyloxy-3,3-difluoro-4-hydroxy-2-oxo-pentyl ester

There total 6 articles about [2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-isopropyl-carbamic acid 5-benzyloxy-3,3-difluoro-4-hydroxy-2-oxo-pentyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 60656-87-3
benzyloxyacetoaldehyde

: 255715-00-5
[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-isopropyl-carbamic acid 2,2-difluoro-1-(1-hydroxy-ethyl)-vinyl ester

: 255715-06-1
[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-isopropyl-carbamic acid 5-benzyloxy-3,3-difluoro-4-hydroxy-2-oxo-pentyl ester

Guidance literature:: [2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-isopropyl-carbamic acid 2,2-difluoro-1-(1-hydroxy-ethyl)-vinyl ester; With n-butyllithium; In tetrahydrofuran; at -78 - -10 ℃;

benzyloxyacetoaldehyde; at -10 ℃;
DOI:10.1039/a907174a

Reference yield:

: 109-56-8
i-propyl(2-(hydroxy)ethyl)amine

: 255715-06-1
[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-isopropyl-carbamic acid 5-benzyloxy-3,3-difluoro-4-hydroxy-2-oxo-pentyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: DMAP / CH₂Cl₂ / 12 h / Heating

2.1: Et₃N / CH₂Cl₂ / 16 h / 0 - 20 °C

3.1: tetrahydrofuran / 16 h / Heating

4.1: LDA / tetrahydrofuran

4.2: 87 percent / BF₃*Et₂O / tetrahydrofuran / -78 - 0 °C

5.1: BuLi / tetrahydrofuran / -78 - -10 °C

5.2: 63 percent / -10 °C

With dmap; n-butyllithium; triethylamine; lithium diisopropyl amide; In tetrahydrofuran; dichloromethane; 1.1: Substitution / 2.1: Acylation / 3.1: Substitution / 4.1: Dehydrofluorination / 4.2: Addition / 5.1: Metallation / 5.2: Addition;
DOI:10.1039/a907174a

Reference yield:

: 58479-61-1
tert-butylchlorodiphenylsilane

: 255715-06-1
[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-isopropyl-carbamic acid 5-benzyloxy-3,3-difluoro-4-hydroxy-2-oxo-pentyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: DMAP / CH₂Cl₂ / 12 h / Heating

2.1: Et₃N / CH₂Cl₂ / 16 h / 0 - 20 °C

3.1: tetrahydrofuran / 16 h / Heating

4.1: LDA / tetrahydrofuran

4.2: 87 percent / BF₃*Et₂O / tetrahydrofuran / -78 - 0 °C

5.1: BuLi / tetrahydrofuran / -78 - -10 °C

5.2: 63 percent / -10 °C

With dmap; n-butyllithium; triethylamine; lithium diisopropyl amide; In tetrahydrofuran; dichloromethane; 1.1: Substitution / 2.1: Acylation / 3.1: Substitution / 4.1: Dehydrofluorination / 4.2: Addition / 5.1: Metallation / 5.2: Addition;
DOI:10.1039/a907174a