(S)-1-[(S)-3-Methyl-2-(4-sulfamoyl-benzoylamino)-butyryl]-pyrrolidine-2-carboxylic acid [(S)-1-(benzooxazol-2-yl-hydroxy-methyl)-2-methyl-propyl]-amide

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Chemical Name:(S)-1-[(S)-3-Methyl-2-(4-sulfamoyl-benzoylamino)-butyryl]-pyrrolidine-2-carboxylic acid [(S)-1-(benzooxazol-2-yl-hydroxy-methyl)-2-methyl-propyl]-amide
CAS No.:1025915-96-1
Molecular Formula:C₂₉H₃₇N₅O₇S
Molecular Weight:599.708
Hs Code.:

(S)-1-[(S)-3-Methyl-2-(4-sulfamoyl-benzoylamino)-butyryl]-pyrrolidine-2-carboxylic acid [(S)-1-(benzooxazol-2-yl-hydroxy-methyl)-2-methyl-propyl]-amide

Synonyms:(S)-1-[(S)-3-Methyl-2-(4-sulfamoyl-benzoylamino)-butyryl]-pyrrolidine-2-carboxylic acid [(S)-1-(benzooxazol-2-yl-hydroxy-methyl)-2-methyl-propyl]-amide

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Chemical Property of (S)-1-[(S)-3-Methyl-2-(4-sulfamoyl-benzoylamino)-butyryl]-pyrrolidine-2-carboxylic acid [(S)-1-(benzooxazol-2-yl-hydroxy-methyl)-2-methyl-propyl]-amide

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Technology Process of (S)-1-[(S)-3-Methyl-2-(4-sulfamoyl-benzoylamino)-butyryl]-pyrrolidine-2-carboxylic acid [(S)-1-(benzooxazol-2-yl-hydroxy-methyl)-2-methyl-propyl]-amide

There total 6 articles about (S)-1-[(S)-3-Methyl-2-(4-sulfamoyl-benzoylamino)-butyryl]-pyrrolidine-2-carboxylic acid [(S)-1-(benzooxazol-2-yl-hydroxy-methyl)-2-methyl-propyl]-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 95501-78-3
N-Benzyloxycarbonyl-L-valyl-L-prolyl-L-valinal

: 1025915-96-1
(S)-1-[(S)-3-Methyl-2-(4-sulfamoyl-benzoylamino)-butyryl]-pyrrolidine-2-carboxylic acid [(S)-1-(benzooxazol-2-yl-hydroxy-methyl)-2-methyl-propyl]-amide

Guidance literature:: Multi-step reaction with 5 steps

1: water / tetrahydrofuran / 4.5 h / Ambient temperature

2: acetyl chloride / CHCl₃ / 16 h / Ambient temperature

3: 35 percent / ethanol / 4 h / 60 °C

4: 96 percent / H₂ / 10percent Pd/C / ethanol / 6 h / 2585.7 Torr

5: 1-ethyl-3-<3-(dimethylamino)propyl>carbodiimide hydrochloride, 1-hydroxybenzotriazole monohydrate / tetrahydrofuran / 16 h / Ambient temperature

With water; hydrogen; 1-hydroxybenzotriazol-hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; acetyl chloride; palladium on activated charcoal; In tetrahydrofuran; ethanol; chloroform;
DOI:10.1021/jm00020a011

Reference yield:

: 95-55-6
2-amino-phenol

: 1025915-96-1
(S)-1-[(S)-3-Methyl-2-(4-sulfamoyl-benzoylamino)-butyryl]-pyrrolidine-2-carboxylic acid [(S)-1-(benzooxazol-2-yl-hydroxy-methyl)-2-methyl-propyl]-amide

Guidance literature:: Multi-step reaction with 3 steps

1: 35 percent / ethanol / 4 h / 60 °C

2: 96 percent / H₂ / 10percent Pd/C / ethanol / 6 h / 2585.7 Torr

3: 1-ethyl-3-<3-(dimethylamino)propyl>carbodiimide hydrochloride, 1-hydroxybenzotriazole monohydrate / tetrahydrofuran / 16 h / Ambient temperature

With hydrogen; 1-hydroxybenzotriazol-hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; palladium on activated charcoal; In tetrahydrofuran; ethanol;
DOI:10.1021/jm00020a011

Reference yield:

: <(benzyloxycarbonyl)-L-valyl>-N-<1-(cyanohydroxymethyl)-2-methylpropyl>-L-prolinamide

: 1025915-96-1
(S)-1-[(S)-3-Methyl-2-(4-sulfamoyl-benzoylamino)-butyryl]-pyrrolidine-2-carboxylic acid [(S)-1-(benzooxazol-2-yl-hydroxy-methyl)-2-methyl-propyl]-amide

Guidance literature:: Multi-step reaction with 4 steps

1: acetyl chloride / CHCl₃ / 16 h / Ambient temperature

2: 35 percent / ethanol / 4 h / 60 °C

3: 96 percent / H₂ / 10percent Pd/C / ethanol / 6 h / 2585.7 Torr

4: 1-ethyl-3-<3-(dimethylamino)propyl>carbodiimide hydrochloride, 1-hydroxybenzotriazole monohydrate / tetrahydrofuran / 16 h / Ambient temperature

With hydrogen; 1-hydroxybenzotriazol-hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; acetyl chloride; palladium on activated charcoal; In tetrahydrofuran; ethanol; chloroform;
DOI:10.1021/jm00020a011