Technology Process of (2'R,2S,3R,4S)-5-<2'-methoxy-2'-(trifluoromethyl)phenylacetoxy>-2,3,4-trimethyl-3,4-methylenedioxypentanoic acid
There total 10 articles about (2'R,2S,3R,4S)-5-<2'-methoxy-2'-(trifluoromethyl)phenylacetoxy>-2,3,4-trimethyl-3,4-methylenedioxypentanoic acid which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 8 steps
1: H2 / 5percent Pd/C / ethyl acetate / 2 h / Ambient temperature
2: 74 percent / tetrahydrofuran; diethyl ether / 5 h / 0 °C
3: 93 percent / LiAlH4 / diethyl ether / 2 h / Heating
4: 4-dimethylaminopyridine / toluene / 2 h / Ambient temperature
5: 83 percent / POCl3, pyridine / 17 h / 85 °C
6: 1.) BH3*THF, 2.) H2O2, NaOH / 1.) THF, 0 deg C, 20 h, 2.) room temperature, 3 h
7: dimethyl sulfoxide, (COCl)2, Et3N / CH2Cl2 / 1 h / -78 °C
8: 1M KMnO4 / 2-methyl-propan-2-ol / 0.08 h / Ambient temperature; 1M phosphate buffer (pH 7)
With
pyridine; dmap; sodium hydroxide; potassium permanganate; lithium aluminium tetrahydride; borane-THF; oxalyl dichloride; hydrogen; dihydrogen peroxide; dimethyl sulfoxide; triethylamine; trichlorophosphate;
palladium on activated charcoal;
In
tetrahydrofuran; diethyl ether; dichloromethane; ethyl acetate; toluene; tert-butyl alcohol;
DOI:10.1016/S0040-4039(00)80702-9
- Guidance literature:
-
With
potassium permanganate;
In
tert-butyl alcohol;
for 0.0833333h;
Ambient temperature;
1M phosphate buffer (pH 7);
DOI:10.1016/S0040-4039(00)80702-9
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 1) BH3*THF, 2) 3 M NaOH, 30percent H2O2 / 1) THF, 0 deg C, 20 h, 2) THF, r.t., 3 h
2: 1) (COCl)2, DMSO, 2) Et3N / 1) CH2Cl2, -78 deg C, 2 min, 2) CH2Cl2, -78 deg C, 1 h
3: 1 M KMnO4 / 2-methyl-propan-2-ol / 0.08 h / pH 7 phosphate buffer
With
sodium hydroxide; potassium permanganate; borane-THF; oxalyl dichloride; dihydrogen peroxide; dimethyl sulfoxide; triethylamine;
In
tert-butyl alcohol;
DOI:10.1016/S0040-4020(01)88350-2
![(4R,5S)-4,5-Dimethyl-[1,3]dioxolane-4,5-dicarboxylic acid 4-methyl ester 5-((R)-1-phenyl-ethyl) ester](/Databaselist/images/loading.webp)
