(2'R,2S,3R,4S)-5-<2'-methoxy-2'-(trifluoromethyl)phenylacetoxy>-2,3,4-trimethyl-3,4-methylenedioxypentanoic acid

Base Information

Chemical Name:(2'R,2S,3R,4S)-5-<2'-methoxy-2'-(trifluoromethyl)phenylacetoxy>-2,3,4-trimethyl-3,4-methylenedioxypentanoic acid
CAS No.:121719-96-8
Molecular Formula:C₁₉H₂₃F₃O₇
Molecular Weight:420.383
Hs Code.:

Synonyms:(2'R,2S,3R,4S)-5-<2'-methoxy-2'-(trifluoromethyl)phenylacetoxy>-2,3,4-trimethyl-3,4-methylenedioxypentanoic acid

Suppliers and Price of (2'R,2S,3R,4S)-5-<2'-methoxy-2'-(trifluoromethyl)phenylacetoxy>-2,3,4-trimethyl-3,4-methylenedioxypentanoic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (2'R,2S,3R,4S)-5-<2'-methoxy-2'-(trifluoromethyl)phenylacetoxy>-2,3,4-trimethyl-3,4-methylenedioxypentanoic acid

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (2'R,2S,3R,4S)-5-<2'-methoxy-2'-(trifluoromethyl)phenylacetoxy>-2,3,4-trimethyl-3,4-methylenedioxypentanoic acid

There total 10 articles about (2'R,2S,3R,4S)-5-<2'-methoxy-2'-(trifluoromethyl)phenylacetoxy>-2,3,4-trimethyl-3,4-methylenedioxypentanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 121719-89-9,121787-07-3
(4R,5S)-4,5-Dimethyl-[1,3]dioxolane-4,5-dicarboxylic acid 4-methyl ester 5-((R)-1-phenyl-ethyl) ester

: 121719-96-8
(2'R,2S,3R,4S)-5-<2'-methoxy-2'-(trifluoromethyl)phenylacetoxy>-2,3,4-trimethyl-3,4-methylenedioxypentanoic acid

Guidance literature:: Multi-step reaction with 8 steps

1: H₂ / 5percent Pd/C / ethyl acetate / 2 h / Ambient temperature

2: 74 percent / tetrahydrofuran; diethyl ether / 5 h / 0 °C

3: 93 percent / LiAlH₄ / diethyl ether / 2 h / Heating

4: 4-dimethylaminopyridine / toluene / 2 h / Ambient temperature

5: 83 percent / POCl₃, pyridine / 17 h / 85 °C

6: 1.) BH₃*THF, 2.) H₂O₂, NaOH / 1.) THF, 0 deg C, 20 h, 2.) room temperature, 3 h

7: dimethyl sulfoxide, (COCl)2, Et₃N / CH₂Cl₂ / 1 h / -78 °C

8: 1M KMnO₄ / 2-methyl-propan-2-ol / 0.08 h / Ambient temperature; 1M phosphate buffer (pH 7)

With pyridine; dmap; sodium hydroxide; potassium permanganate; lithium aluminium tetrahydride; borane-THF; oxalyl dichloride; hydrogen; dihydrogen peroxide; dimethyl sulfoxide; triethylamine; trichlorophosphate; palladium on activated charcoal; In tetrahydrofuran; diethyl ether; dichloromethane; ethyl acetate; toluene; tert-butyl alcohol;
DOI:10.1016/S0040-4039(00)80702-9

Reference yield:

: 146070-68-0
(R)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (4S,5R)-4,5-dimethyl-5-((R)-1-methyl-2-oxo-ethyl)-[1,3]dioxolan-4-ylmethyl ester

: 121719-96-8
(2'R,2S,3R,4S)-5-<2'-methoxy-2'-(trifluoromethyl)phenylacetoxy>-2,3,4-trimethyl-3,4-methylenedioxypentanoic acid

Guidance literature:: With potassium permanganate; In tert-butyl alcohol; for 0.0833333h; Ambient temperature; 1M phosphate buffer (pH 7);
DOI:10.1016/S0040-4039(00)80702-9

Reference yield:

: 121719-94-6
(2'R,3R,4S)-5-<2'-methoxy-2'-(trifluoromethyl)phenylacetoxy>-2,3,4-trimethyl-3,4-methylenedioxy-2-pentene

: 121719-96-8
(2'R,2S,3R,4S)-5-<2'-methoxy-2'-(trifluoromethyl)phenylacetoxy>-2,3,4-trimethyl-3,4-methylenedioxypentanoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 1) BH₃*THF, 2) 3 M NaOH, 30percent H₂O₂ / 1) THF, 0 deg C, 20 h, 2) THF, r.t., 3 h

2: 1) (COCl)2, DMSO, 2) Et₃N / 1) CH₂Cl₂, -78 deg C, 2 min, 2) CH₂Cl₂, -78 deg C, 1 h

3: 1 M KMnO₄ / 2-methyl-propan-2-ol / 0.08 h / pH 7 phosphate buffer

With sodium hydroxide; potassium permanganate; borane-THF; oxalyl dichloride; dihydrogen peroxide; dimethyl sulfoxide; triethylamine; In tert-butyl alcohol;
DOI:10.1016/S0040-4020(01)88350-2