(R)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (4S,5R)-4,5-dimethyl-5-((R)-1-methyl-2-oxo-ethyl)-[1,3]dioxolan-4-ylmethyl ester

Base Information

Chemical Name:(R)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (4S,5R)-4,5-dimethyl-5-((R)-1-methyl-2-oxo-ethyl)-[1,3]dioxolan-4-ylmethyl ester
CAS No.:146070-68-0
Molecular Formula:C₁₉H₂₃F₃O₆
Molecular Weight:404.383
Hs Code.:

Synonyms:(R)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (4S,5R)-4,5-dimethyl-5-((R)-1-methyl-2-oxo-ethyl)-[1,3]dioxolan-4-ylmethyl ester

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Chemical Property of (R)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (4S,5R)-4,5-dimethyl-5-((R)-1-methyl-2-oxo-ethyl)-[1,3]dioxolan-4-ylmethyl ester

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Technology Process of (R)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (4S,5R)-4,5-dimethyl-5-((R)-1-methyl-2-oxo-ethyl)-[1,3]dioxolan-4-ylmethyl ester

There total 9 articles about (R)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (4S,5R)-4,5-dimethyl-5-((R)-1-methyl-2-oxo-ethyl)-[1,3]dioxolan-4-ylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 121719-95-7,121787-09-5
(2'R,2S,3R,4S)-5-<2'-methoxy-2'-(trifluoromethyl)phenylacetoxy>-2,3,4-trimethyl-3,4-methylenedioxy-1-pentanol

: 146070-68-0
(R)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (4S,5R)-4,5-dimethyl-5-((R)-1-methyl-2-oxo-ethyl)-[1,3]dioxolan-4-ylmethyl ester

Guidance literature:: With oxalyl dichloride; dimethyl sulfoxide; triethylamine; In dichloromethane; at -78 ℃; for 1h;
DOI:10.1016/S0040-4039(00)80702-9

Reference yield:

: 121719-89-9,121787-07-3
(4R,5S)-4,5-Dimethyl-[1,3]dioxolane-4,5-dicarboxylic acid 4-methyl ester 5-((R)-1-phenyl-ethyl) ester

: 146070-68-0
(R)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (4S,5R)-4,5-dimethyl-5-((R)-1-methyl-2-oxo-ethyl)-[1,3]dioxolan-4-ylmethyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: H₂ / 5percent Pd/C / ethyl acetate / 2 h / Ambient temperature

2: 74 percent / tetrahydrofuran; diethyl ether / 5 h / 0 °C

3: 93 percent / LiAlH₄ / diethyl ether / 2 h / Heating

4: 4-dimethylaminopyridine / toluene / 2 h / Ambient temperature

5: 83 percent / POCl₃, pyridine / 17 h / 85 °C

6: 1.) BH₃*THF, 2.) H₂O₂, NaOH / 1.) THF, 0 deg C, 20 h, 2.) room temperature, 3 h

7: dimethyl sulfoxide, (COCl)2, Et₃N / CH₂Cl₂ / 1 h / -78 °C

With pyridine; dmap; sodium hydroxide; lithium aluminium tetrahydride; borane-THF; oxalyl dichloride; hydrogen; dihydrogen peroxide; dimethyl sulfoxide; triethylamine; trichlorophosphate; palladium on activated charcoal; In tetrahydrofuran; diethyl ether; dichloromethane; ethyl acetate; toluene;
DOI:10.1016/S0040-4039(00)80702-9

Reference yield:

: 121719-94-6
(2'R,3R,4S)-5-<2'-methoxy-2'-(trifluoromethyl)phenylacetoxy>-2,3,4-trimethyl-3,4-methylenedioxy-2-pentene

: 146070-68-0
(R)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (4S,5R)-4,5-dimethyl-5-((R)-1-methyl-2-oxo-ethyl)-[1,3]dioxolan-4-ylmethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 1) BH₃*THF, 2) 3 M NaOH, 30percent H₂O₂ / 1) THF, 0 deg C, 20 h, 2) THF, r.t., 3 h

2: 1) (COCl)2, DMSO, 2) Et₃N / 1) CH₂Cl₂, -78 deg C, 2 min, 2) CH₂Cl₂, -78 deg C, 1 h

With sodium hydroxide; borane-THF; oxalyl dichloride; dihydrogen peroxide; dimethyl sulfoxide; triethylamine;
DOI:10.1016/S0040-4020(01)88350-2