(1R,3R,5S)-3-[Bis-(4-fluoro-phenyl)-methoxy]-8-[4-(4-nitro-phenyl)-butyl]-8-aza-bicyclo[3.2.1]octane

Base Information

Chemical Name:(1R,3R,5S)-3-[Bis-(4-fluoro-phenyl)-methoxy]-8-[4-(4-nitro-phenyl)-butyl]-8-aza-bicyclo[3.2.1]octane
CAS No.:203048-96-8
Molecular Formula:C₃₀H₃₂F₂N₂O₃
Molecular Weight:506.592
Hs Code.:

Synonyms:(1R,3R,5S)-3-[Bis-(4-fluoro-phenyl)-methoxy]-8-[4-(4-nitro-phenyl)-butyl]-8-aza-bicyclo[3.2.1]octane

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Chemical Property of (1R,3R,5S)-3-[Bis-(4-fluoro-phenyl)-methoxy]-8-[4-(4-nitro-phenyl)-butyl]-8-aza-bicyclo[3.2.1]octane

Chemical Property:

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Technology Process of (1R,3R,5S)-3-[Bis-(4-fluoro-phenyl)-methoxy]-8-[4-(4-nitro-phenyl)-butyl]-8-aza-bicyclo[3.2.1]octane

There total 4 articles about (1R,3R,5S)-3-[Bis-(4-fluoro-phenyl)-methoxy]-8-[4-(4-nitro-phenyl)-butyl]-8-aza-bicyclo[3.2.1]octane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 202646-05-7
1-{(1R,3R,5S)-3-[Bis-(4-fluoro-phenyl)-methoxy]-8-aza-bicyclo[3.2.1]oct-8-yl}-4-(4-nitro-phenyl)-butan-1-one

: 203048-96-8
(1R,3R,5S)-3-[Bis-(4-fluoro-phenyl)-methoxy]-8-[4-(4-nitro-phenyl)-butyl]-8-aza-bicyclo[3.2.1]octane

Guidance literature:: With lithium aluminium tetrahydride; sulfuric acid; In tetrahydrofuran; for 2h; Yield given; Ambient temperature;
DOI:10.1021/jm970525a

Reference yield:

: 5600-62-4
4-(4-nitrophenyl)butanoic acid

: 203048-96-8
(1R,3R,5S)-3-[Bis-(4-fluoro-phenyl)-methoxy]-8-[4-(4-nitro-phenyl)-butyl]-8-aza-bicyclo[3.2.1]octane

Guidance literature:: Multi-step reaction with 2 steps

1: DCC, HOBt

2: AlH₃ / tetrahydrofuran / 4 h

With aluminium hydride; benzotriazol-1-ol; dicyclohexyl-carbodiimide; In tetrahydrofuran;
DOI:10.1016/S0960-894X(97)10139-1

Reference yield:

: (1R,3R,5S)-3-[Bis-(4-fluoro-phenyl)-methoxy]-8-aza-bicyclo[3.2.1]octane; hydrochloride

: 203048-96-8
(1R,3R,5S)-3-[Bis-(4-fluoro-phenyl)-methoxy]-8-[4-(4-nitro-phenyl)-butyl]-8-aza-bicyclo[3.2.1]octane

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine, dicyclohexylcarbodiimide, 1-hydroxybenzotriazole hydrate / dimethylformamide / 48 h / Ambient temperature

2: LiAlH₄, 98percent H₂SO₄ / tetrahydrofuran / 2 h / Ambient temperature

With lithium aluminium tetrahydride; sulfuric acid; 1-hydroxybenzotriazol-hydrate; triethylamine; dicyclohexyl-carbodiimide; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/jm970525a