3,4-Dihydro-1H-isoquinoline-2-carboxylic acid [(S)-1-(1-benzyl-3-fluoro-2-hydroxy-propylcarbamoyl)-3-methyl-butyl]-amide

Base Information

Chemical Name:3,4-Dihydro-1H-isoquinoline-2-carboxylic acid [(S)-1-(1-benzyl-3-fluoro-2-hydroxy-propylcarbamoyl)-3-methyl-butyl]-amide
CAS No.:197855-47-3
Molecular Formula:C₂₆H₃₄FN₃O₃
Molecular Weight:455.573
Hs Code.:

Synonyms:3,4-Dihydro-1H-isoquinoline-2-carboxylic acid [(S)-1-(1-benzyl-3-fluoro-2-hydroxy-propylcarbamoyl)-3-methyl-butyl]-amide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3,4-Dihydro-1H-isoquinoline-2-carboxylic acid [(S)-1-(1-benzyl-3-fluoro-2-hydroxy-propylcarbamoyl)-3-methyl-butyl]-amide

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 3,4-Dihydro-1H-isoquinoline-2-carboxylic acid [(S)-1-(1-benzyl-3-fluoro-2-hydroxy-propylcarbamoyl)-3-methyl-butyl]-amide

There total 6 articles about 3,4-Dihydro-1H-isoquinoline-2-carboxylic acid [(S)-1-(1-benzyl-3-fluoro-2-hydroxy-propylcarbamoyl)-3-methyl-butyl]-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 5153-67-3
nitrostyrene

: 197855-47-3
3,4-Dihydro-1H-isoquinoline-2-carboxylic acid [(S)-1-(1-benzyl-3-fluoro-2-hydroxy-propylcarbamoyl)-3-methyl-butyl]-amide

Guidance literature:: Multi-step reaction with 4 steps

1: 2.86 g / NaBH₄, silica gel / CHCl₃; propan-2-ol / 0.25 h

2: Et₃N / Ambient temperature

3: H₂ / Raney Ni / ethanol; H₂O / 5 h / 3102.9 Torr

4: 1.) 1-HOBt, BOP, N-methylmorpholine / 1.) DMF, 0 deg C, 10 min, 2.) DMF, from 0 to 23 deg C

With 4-methyl-morpholine; sodium tetrahydroborate; hydrogen; silica gel; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; benzotriazol-1-ol; triethylamine; nickel; In ethanol; chloroform; water; isopropyl alcohol;
DOI:10.1021/jm970197e

Reference yield:

: 6125-24-2
2-Phenylnitroethane

: 197855-47-3
3,4-Dihydro-1H-isoquinoline-2-carboxylic acid [(S)-1-(1-benzyl-3-fluoro-2-hydroxy-propylcarbamoyl)-3-methyl-butyl]-amide

Guidance literature:: Multi-step reaction with 3 steps

1: Et₃N / Ambient temperature

2: H₂ / Raney Ni / ethanol; H₂O / 5 h / 3102.9 Torr

3: 1.) 1-HOBt, BOP, N-methylmorpholine / 1.) DMF, 0 deg C, 10 min, 2.) DMF, from 0 to 23 deg C

With 4-methyl-morpholine; hydrogen; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; benzotriazol-1-ol; triethylamine; nickel; In ethanol; water;
DOI:10.1021/jm970197e

Reference yield:

: 102195-94-8
1-Fluoro-2-hydroxy-3-nitro-4-phenylbutane

: 197855-47-3
3,4-Dihydro-1H-isoquinoline-2-carboxylic acid [(S)-1-(1-benzyl-3-fluoro-2-hydroxy-propylcarbamoyl)-3-methyl-butyl]-amide

Guidance literature:: Multi-step reaction with 2 steps

1: H₂ / Raney Ni / ethanol; H₂O / 5 h / 3102.9 Torr

2: 1.) 1-HOBt, BOP, N-methylmorpholine / 1.) DMF, 0 deg C, 10 min, 2.) DMF, from 0 to 23 deg C

With 4-methyl-morpholine; hydrogen; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; benzotriazol-1-ol; nickel; In ethanol; water;
DOI:10.1021/jm970197e