Methylphenidate

Base Information Edit

Chemical Name:Methylphenidate
CAS No.:113-45-1
Molecular Formula:C14H19 N O2
Molecular Weight:233.31
Hs Code.:
European Community (EC) Number:204-028-6
DSSTox Substance ID:DTXSID5023299
Nikkaji Number:J5.133K
Wikipedia:Methylphenidate
Wikidata:Q422112
NCI Thesaurus Code:C62045
RXCUI:6901
Pharos Ligand ID:AS1ZHKH1VYVD
Metabolomics Workbench ID:143610
ChEMBL ID:CHEMBL796
Mol file:113-45-1.mol

Synonyms:Centedrin;Concerta;Daytrana;Equasym;Hydrochloride, Methylphenidate;Metadate;Methylin;Methylphenidate;Methylphenidate Hydrochloride;Phenidylate;Ritalin;Ritalin SR;Ritalin-SR;Ritaline;Tsentedrin

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Chemical Property of Methylphenidate Edit

Chemical Property:

Vapor Pressure:0.000199mmHg at 25°C
Melting Point:74.5°C
Refractive Index:1.5110 (estimate)
Boiling Point:327.6°Cat760mmHg
PKA:9.51±0.10(Predicted)
Flash Point:152°C
PSA：38.33000
Density:1.07g/cm³
LogP:2.41410
XLogP3:0.2
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:4
Exact Mass:233.141578849
Heavy Atom Count:17
Complexity:249

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Drug Classes:Central Nervous System Stimulants
Canonical SMILES:COC(=O)C(C1CCCCN1)C2=CC=CC=C2
Recent ClinicalTrials:Multimodal Brain Imaging of the Neural Effects of Methylphenidate in Patients With ADHD
Recent EU Clinical Trials:LAMAinDiab - lisdexamphetamine vs methylphenidate for pediatric patients with ADHD and type 1 diabetes - a randomized crossover clinical trial .
Recent NIPH Clinical Trials:The prediction of effects and side effects of ADHD treatment drugs (atomoxetine and methylphenidate).
Uses Methylphenidate's mode of action is not completely known, but it is believed that ADHD symptoms are related to the dopaminergic areas of the brain. Animal studies indicate that methylphenidate affects several neurotransmitters to counteract ADHD behavior. Methylphenidate binds to dopamine transporters in the presynaptic neuron, blocking the reuptake of dopamine and increasing extracellular dopamine. Methylphenidate also infl uences norepinephrine reuptake and infl uences serotonin to a minor degree. In addition to ADHD, methylphenidate is used for several other medical conditions.It continues to be used for narcolepsy. It has also been used in treating depression, especially in elderly populations. Methylphenidate has been suggested for use in the treatment of brain injury from stroke or brain trauma; it has also been suggested to improve appetite and the mood of cancer and HIV patients. Another use is for pain control and/or sedation for patients using opiates.Health concerns are associated with the use of methylphenidate.Some of the commonly reported adverse effects associated with its use are insomnia, nervousness, hypertension, headache, anorexia, and tachycardia;less common effects include weight loss, nausea, and angina. Studies have indicated that methylphenidate lead to liver tumors in mice, but limited studies on its carcinogenicity in animals have not led the FDA to change recommendations on its use. Because methylphenidate is a stimulant and readily available, it has a potential for drug abuse. Stimulant.
Therapeutic Function Psychostimulant

Technology Process of Methylphenidate

There total 82 articles about Methylphenidate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%