3-[2(R)-tert-butoxycarbonylamino-2-phenylethyl]-5-bromo-1-[2-bromo-6-fluorobenzyl]-6-methylpyrimidine-2,4(1H,3H)-dione

Base Information

• Chemical Name: 3-[2(R)-tert-butoxycarbonylamino-2-phenylethyl]-5-bromo-1-[2-bromo-6-fluorobenzyl]-6-methylpyrimidine-2,4(1H,3H)-dione
• CAS No.: 832711-51-0
• Molecular Formula: C₂₅H₂₆BrClFN₃O₄
• Molecular Weight: 566.855

Synonyms:3-[2(R)-tert-butoxycarbonylamino-2-phenylethyl]-5-bromo-1-[2-bromo-6-fluorobenzyl]-6-methylpyrimidine-2,4(1H,3H)-dione

Chemical Property of 3-[2(R)-tert-butoxycarbonylamino-2-phenylethyl]-5-bromo-1-[2-bromo-6-fluorobenzyl]-6-methylpyrimidine-2,4(1H,3H)-dione

Chemical Property:

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Technology Process of 3-[2(R)-tert-butoxycarbonylamino-2-phenylethyl]-5-bromo-1-[2-bromo-6-fluorobenzyl]-6-methylpyrimidine-2,4(1H,3H)-dione

There total 1 articles about 3-[2(R)-tert-butoxycarbonylamino-2-phenylethyl]-5-bromo-1-[2-bromo-6-fluorobenzyl]-6-methylpyrimidine-2,4(1H,3H)-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

5-bromo-1-[2-bromo-6-fluorobenzyl]-6-methylpyrimidine-2,4(1H,3H)-dione (832711-70-3) + (R)-N-(tert-butoxycarbonyl)phenylglycinol (67341-01-9,117049-14-6,138457-46-2,102089-74-7) → 3-[2(R)-tert-butoxycarbonylamino-2-phenylethyl]-5-bromo-1-[2-bromo-6-fluorobenzyl]-6-methylpyrimidine-2,4(1H,3H)-dione (832711-51-0)

Guidance literature:

With di-tert-butyl-diazodicarboxylate; triphenylphosphine; In tetrahydrofuran; at 20 ℃; for 16h;

Reference yield: 98.0%

3-[2(R)-tert-butoxycarbonylamino-2-phenylethyl]-5-bromo-1-[2-bromo-6-fluorobenzyl]-6-methylpyrimidine-2,4(1H,3H)-dione (832711-51-0) + 3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol (214360-76-6) → 3-[2(R)-tert-butoxycarbonylamino-2-phenylethyl]-5-(3-hydroxyphenyl)-1-[2-bromo-6-fluorobenzyl]-6-methylpyrimidine-2,4(1H,3H)-dione (832711-04-3)

Guidance literature:

With barium dihydroxide; potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In ethanol; water; toluene; at 100 ℃; for 16h;

Reference yield:

3-[2(R)-tert-butoxycarbonylamino-2-phenylethyl]-5-bromo-1-[2-bromo-6-fluorobenzyl]-6-methylpyrimidine-2,4(1H,3H)-dione (832711-51-0) + (2-fluoro-3-methoxyphenyl)boronic acid (352303-67-4) → C32H32ClF2N3O5

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In 1,4-dioxane; water; at 90 ℃; for 16h;

DOI:10.1021/jm8006454

upstream raw materials:

5-bromo-1-[2-bromo-6-fluorobenzyl]-6-methylpyrimidine-2,4(1H,3H)-dione

(R)-N-(tert-butoxycarbonyl)phenylglycinol

Downstream raw materials:

3-[2(R)-tert-butoxycarbonylamino-2-phenylethyl]-5-(3-hydroxyphenyl)-1-[2-bromo-6-fluorobenzyl]-6-methylpyrimidine-2,4(1H,3H)-dione

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