(2R,4R,5R)-[2-(2-benzyloxyethyl)-5-(2,2-dimethyl-[1,3]dioxolan-4(S)-4-yl)-tetrahydrofuran-3-yloxy]-tert-butyldiphenylsilane

Base Information

Chemical Name:(2R,4R,5R)-[2-(2-benzyloxyethyl)-5-(2,2-dimethyl-[1,3]dioxolan-4(S)-4-yl)-tetrahydrofuran-3-yloxy]-tert-butyldiphenylsilane
CAS No.:329010-33-5
Molecular Formula:C₃₄H₄₄O₅Si
Molecular Weight:560.806
Hs Code.:

Synonyms:(2R,4R,5R)-[2-(2-benzyloxyethyl)-5-(2,2-dimethyl-[1,3]dioxolan-4(S)-4-yl)-tetrahydrofuran-3-yloxy]-tert-butyldiphenylsilane

Suppliers and Price of (2R,4R,5R)-[2-(2-benzyloxyethyl)-5-(2,2-dimethyl-[1,3]dioxolan-4(S)-4-yl)-tetrahydrofuran-3-yloxy]-tert-butyldiphenylsilane

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (2R,4R,5R)-[2-(2-benzyloxyethyl)-5-(2,2-dimethyl-[1,3]dioxolan-4(S)-4-yl)-tetrahydrofuran-3-yloxy]-tert-butyldiphenylsilane

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (2R,4R,5R)-[2-(2-benzyloxyethyl)-5-(2,2-dimethyl-[1,3]dioxolan-4(S)-4-yl)-tetrahydrofuran-3-yloxy]-tert-butyldiphenylsilane

There total 11 articles about (2R,4R,5R)-[2-(2-benzyloxyethyl)-5-(2,2-dimethyl-[1,3]dioxolan-4(S)-4-yl)-tetrahydrofuran-3-yloxy]-tert-butyldiphenylsilane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 77-76-9
2,2-dimethoxy-propane

: 329010-30-2
(2S)-1-[(2R,4R,5R)-5-(2-benzyloxyethyl)-4-(tert-butyldiphenylsilanyloxy)-tetrahydrofuran-2-yl]-ethane-1,2-diol

: 329010-33-5
(2R,4R,5R)-[2-(2-benzyloxyethyl)-5-(2,2-dimethyl-[1,3]dioxolan-4(S)-4-yl)-tetrahydrofuran-3-yloxy]-tert-butyldiphenylsilane

Guidance literature:: With camphor-10-sulfonic acid; In dichloromethane; at 0 - 20 ℃; for 2h;
DOI:10.1021/jo0057194

Reference yield:

: 5470-84-8
4-benzyloxybutanal

: 329010-33-5
(2R,4R,5R)-[2-(2-benzyloxyethyl)-5-(2,2-dimethyl-[1,3]dioxolan-4(S)-4-yl)-tetrahydrofuran-3-yloxy]-tert-butyldiphenylsilane

Guidance literature:: Multi-step reaction with 9 steps

1: piperidine / xylene / 5 h / Heating

2: Me₃SiCl / 2 h / 20 °C

3: 90 percent / AD-mix-β; MeSO2NH2 / 2-methyl-propan-2-ol; H2O / 20 h / 0 °C

4: 95 percent / imidazole / CH₂Cl₂ / 0 - 20 °C

5: DIBAL-H / diethyl ether; cyclohexane / -78 °C

6: 5.98 g / benzene / 2 h / 50 °C

7: 82 percent / DIBAL-H / diethyl ether; cyclohexane / 0 °C

8: 80 percent / Ti(OPr-i)4; (R,R)-(+)-DET; TBHP / 4 Angstroem molecular sieves / CH₂Cl₂; 2,2,4-trimethyl-pentane / 2 h / -20 °C

9: 93 percent / CSA / CH₂Cl₂ / 2 h / 0 - 20 °C

With piperidine; 1H-imidazole; titanium(IV) isopropylate; tert.-butylhydroperoxide; chloro-trimethyl-silane; diethyl (2R,3R)-tartrate; methanesulfonamide; AD-mix-β; camphor-10-sulfonic acid; diisobutylaluminium hydride; 4 A molecular sieve; In 2,2,4-trimethylpentane; diethyl ether; dichloromethane; cyclohexane; water; xylene; tert-butyl alcohol; benzene; 1: Knoevenagel condensation / 6: Wittig olefination / 8: Katsuki-Sharpless asymmetric epoxidation;
DOI:10.1021/jo0057194

Reference yield:

: 4541-14-4
4-benzyloxy-butan-1-ol

: 329010-33-5
(2R,4R,5R)-[2-(2-benzyloxyethyl)-5-(2,2-dimethyl-[1,3]dioxolan-4(S)-4-yl)-tetrahydrofuran-3-yloxy]-tert-butyldiphenylsilane

Guidance literature:: Multi-step reaction with 10 steps

1: Et₃N; DMSO; SO₃*Py / CH₂Cl₂ / 2 h / 0 - 20 °C

2: piperidine / xylene / 5 h / Heating

3: Me₃SiCl / 2 h / 20 °C

4: 90 percent / AD-mix-β; MeSO2NH2 / 2-methyl-propan-2-ol; H2O / 20 h / 0 °C

5: 95 percent / imidazole / CH₂Cl₂ / 0 - 20 °C

6: DIBAL-H / diethyl ether; cyclohexane / -78 °C

7: 5.98 g / benzene / 2 h / 50 °C

8: 82 percent / DIBAL-H / diethyl ether; cyclohexane / 0 °C

9: 80 percent / Ti(OPr-i)4; (R,R)-(+)-DET; TBHP / 4 Angstroem molecular sieves / CH₂Cl₂; 2,2,4-trimethyl-pentane / 2 h / -20 °C

10: 93 percent / CSA / CH₂Cl₂ / 2 h / 0 - 20 °C

With piperidine; 1H-imidazole; titanium(IV) isopropylate; tert.-butylhydroperoxide; chloro-trimethyl-silane; pyridine-SO₃ complex; diethyl (2R,3R)-tartrate; methanesulfonamide; AD-mix-β; camphor-10-sulfonic acid; diisobutylaluminium hydride; dimethyl sulfoxide; triethylamine; 4 A molecular sieve; In 2,2,4-trimethylpentane; diethyl ether; dichloromethane; cyclohexane; water; xylene; tert-butyl alcohol; benzene; 2: Knoevenagel condensation / 7: Wittig olefination / 9: Katsuki-Sharpless asymmetric epoxidation;
DOI:10.1021/jo0057194