(3aS,5aR)-5a-benzyl-2,3,3a,4-tetrahydro-1H,5aH-5-oxa-10a,10b-diazacyclopenta[a]fluoren-10-one

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Chemical Name:(3aS,5aR)-5a-benzyl-2,3,3a,4-tetrahydro-1H,5aH-5-oxa-10a,10b-diazacyclopenta[a]fluoren-10-one
CAS No.:1341154-64-0
Molecular Formula:C₂₀H₂₀N₂O₂
Molecular Weight:320.391
Hs Code.:

Synonyms:(3aS,5aR)-5a-benzyl-2,3,3a,4-tetrahydro-1H,5aH-5-oxa-10a,10b-diazacyclopenta[a]fluoren-10-one

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Chemical Property of (3aS,5aR)-5a-benzyl-2,3,3a,4-tetrahydro-1H,5aH-5-oxa-10a,10b-diazacyclopenta[a]fluoren-10-one

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Technology Process of (3aS,5aR)-5a-benzyl-2,3,3a,4-tetrahydro-1H,5aH-5-oxa-10a,10b-diazacyclopenta[a]fluoren-10-one

There total 5 articles about (3aS,5aR)-5a-benzyl-2,3,3a,4-tetrahydro-1H,5aH-5-oxa-10a,10b-diazacyclopenta[a]fluoren-10-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 1341154-37-7
(3aS,5aR)-2,3,3a,4-tetrahydro-1H,5aH-5-oxa-10a,10b-diazacyclopenta[a]fluoren-10-one

: 100-39-0
benzyl bromide

: 1341154-64-0
(3aS,5aR)-5a-benzyl-2,3,3a,4-tetrahydro-1H,5aH-5-oxa-10a,10b-diazacyclopenta[a]fluoren-10-one

Guidance literature:: (3aS,5aR)-2,3,3a,4-tetrahydro-1H,5aH-5-oxa-10a,10b-diazacyclopenta[a]fluoren-10-one; With potassium hexamethylsilazane; In tetrahydrofuran; toluene; at -78 - -50 ℃; for 0.5h;

benzyl bromide; In tetrahydrofuran; toluene; at -78 - 20 ℃; for 3.5h; optical yield given as %de;
DOI:10.1016/j.tetasy.2011.07.020

Reference yield:

: 85-44-9
phthalic anhydride

: 1341154-64-0
(3aS,5aR)-5a-benzyl-2,3,3a,4-tetrahydro-1H,5aH-5-oxa-10a,10b-diazacyclopenta[a]fluoren-10-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: toluene-4-sulfonic acid / toluene / 5 h / Reflux

2.1: sodium tetrahydroborate / methanol / 0.5 h / 0 °C

3.1: toluene-4-sulfonic acid / toluene / Reflux

4.1: potassium hexamethylsilazane / tetrahydrofuran; toluene / 0.5 h / -78 - -50 °C

4.2: 3.5 h / -78 - 20 °C

With sodium tetrahydroborate; potassium hexamethylsilazane; toluene-4-sulfonic acid; In tetrahydrofuran; methanol; toluene;
DOI:10.1016/j.tetasy.2011.07.020

Reference yield:

: 1341154-40-2
2-[(S)-2-hydroxymethylpyrrolidin-1-yl]-isoindole-1,3-dione

: 1341154-64-0
(3aS,5aR)-5a-benzyl-2,3,3a,4-tetrahydro-1H,5aH-5-oxa-10a,10b-diazacyclopenta[a]fluoren-10-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium tetrahydroborate / methanol / 0.5 h / 0 °C

2.1: toluene-4-sulfonic acid / toluene / Reflux

3.1: potassium hexamethylsilazane / tetrahydrofuran; toluene / 0.5 h / -78 - -50 °C

3.2: 3.5 h / -78 - 20 °C

With sodium tetrahydroborate; potassium hexamethylsilazane; toluene-4-sulfonic acid; In tetrahydrofuran; methanol; toluene;
DOI:10.1016/j.tetasy.2011.07.020