methyl (3,7-anhydro-4,5,6,8-tetra-O-benzyl-3-cyano-2-deoxy-D-glycero-L-manno-oct)onate

Base Information

Chemical Name:methyl (3,7-anhydro-4,5,6,8-tetra-O-benzyl-3-cyano-2-deoxy-D-glycero-L-manno-oct)onate
CAS No.:400888-52-0
Molecular Formula:C₃₈H₃₉NO₇
Molecular Weight:621.73
Hs Code.:

Synonyms:methyl (3,7-anhydro-4,5,6,8-tetra-O-benzyl-3-cyano-2-deoxy-D-glycero-L-manno-oct)onate

Suppliers and Price of methyl (3,7-anhydro-4,5,6,8-tetra-O-benzyl-3-cyano-2-deoxy-D-glycero-L-manno-oct)onate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of methyl (3,7-anhydro-4,5,6,8-tetra-O-benzyl-3-cyano-2-deoxy-D-glycero-L-manno-oct)onate

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of methyl (3,7-anhydro-4,5,6,8-tetra-O-benzyl-3-cyano-2-deoxy-D-glycero-L-manno-oct)onate

There total 4 articles about methyl (3,7-anhydro-4,5,6,8-tetra-O-benzyl-3-cyano-2-deoxy-D-glycero-L-manno-oct)onate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 7677-24-9
trimethylsilyl cyanide

: 400888-43-9
methyl (4,5,6,8-tetra-O-benzyl-2-deoxy-α-D-galacto-3-octulopyranosid)onate

: 400888-52-0
methyl (3,7-anhydro-4,5,6,8-tetra-O-benzyl-3-cyano-2-deoxy-D-glycero-L-manno-oct)onate

Guidance literature:: With trimethylsilyl trifluoromethanesulfonate; In acetonitrile; at 0 - 20 ℃; for 36h;
DOI:10.1016/j.carres.2006.03.006

Reference yield:

: 82598-84-3
2,3,4,6-tetra-O-benzyl-D-galactonolactone

: 400888-52-0
methyl (3,7-anhydro-4,5,6,8-tetra-O-benzyl-3-cyano-2-deoxy-D-glycero-L-manno-oct)onate

Guidance literature:: Multi-step reaction with 4 steps

1: 95 percent / tetrahydrofuran / 1 h / -78 - 20 °C

2: trifluoroacetic acid / CH₂Cl₂ / 2 h / 0 °C

3: 766 mg / cesium carbonate / dimethylformamide / 4 h / 20 °C

4: 75 percent / trimethylsilyl trifluoromethanesulfonate / acetonitrile / 36 h / 0 - 20 °C

With trimethylsilyl trifluoromethanesulfonate; caesium carbonate; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/j.carres.2006.03.006

Reference yield:

: 2-deoxy-α-D-galacto-oct-3-ulopyranosonic acid

: 400888-52-0
methyl (3,7-anhydro-4,5,6,8-tetra-O-benzyl-3-cyano-2-deoxy-D-glycero-L-manno-oct)onate

Guidance literature:: Multi-step reaction with 2 steps

1: 766 mg / cesium carbonate / dimethylformamide / 4 h / 20 °C

2: 75 percent / trimethylsilyl trifluoromethanesulfonate / acetonitrile / 36 h / 0 - 20 °C

With trimethylsilyl trifluoromethanesulfonate; caesium carbonate; In N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/j.carres.2006.03.006