3-[N-[2-benzoyl-4-(N^α-tert-butyloxycarbonyl-S-tritylcysteinylamino)phenyl]carbamoyl]propionic acid

Base Information

• Chemical Name: 3-[N-[2-benzoyl-4-(N^α-tert-butyloxycarbonyl-S-tritylcysteinylamino)phenyl]carbamoyl]propionic acid
• CAS No.: 265648-51-9
• Molecular Formula: C₄₄H₄₃N₃O₇S
• Molecular Weight: 757.907

Synonyms:3-[N-[2-benzoyl-4-(N^α-tert-butyloxycarbonyl-S-tritylcysteinylamino)phenyl]carbamoyl]propionic acid

Chemical Property of 3-[N-[2-benzoyl-4-(N^α-tert-butyloxycarbonyl-S-tritylcysteinylamino)phenyl]carbamoyl]propionic acid

Chemical Property:

Purity/Quality:

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Technology Process of 3-[N-[2-benzoyl-4-(N^α-tert-butyloxycarbonyl-S-tritylcysteinylamino)phenyl]carbamoyl]propionic acid

There total 6 articles about 3-[N-[2-benzoyl-4-(N^α-tert-butyloxycarbonyl-S-tritylcysteinylamino)phenyl]carbamoyl]propionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

3-[N-[2-benzoyl-4-(Nα-tert-butyloxycarbonyl-S-tritylcysteinylamino)phenyl]carbamoyl]propionic acid methyl ester (265648-50-8) → 3-[N-[2-benzoyl-4-(Nα-tert-butyloxycarbonyl-S-tritylcysteinylamino)phenyl]carbamoyl]propionic acid (265648-51-9)

Guidance literature:

With sodium hydroxide; In tetrahydrofuran; methanol; at 20 ℃; for 12h;

DOI:10.1021/jm010872r

Reference yield:

N-tert-butyloxycarbonyl-S-trityl-L-cysteine (21947-98-8,87494-13-1) → 3-[N-[2-benzoyl-4-(Nα-tert-butyloxycarbonyl-S-tritylcysteinylamino)phenyl]carbamoyl]propionic acid (265648-51-9)

Guidance literature:

Multi-step reaction with 3 steps

1: N-methylmorpholine / dimethylformamide / 0.08 h / -15 °C

2: dimethylformamide / -15 - 20 °C

3: 66 percent / 1 N NaOH / tetrahydrofuran; methanol / 12 h / 20 °C

With 4-methyl-morpholine; sodium hydroxide; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;

DOI:10.1021/jm010872r

Reference yield:

Boc-Cys(Trt)-OH → 3-[N-[2-benzoyl-4-(Nα-tert-butyloxycarbonyl-S-tritylcysteinylamino)phenyl]carbamoyl]propionic acid (265648-51-9)

Guidance literature:

Multi-step reaction with 2 steps

1: dimethylformamide / -15 - 20 °C

2: 66 percent / 1 N NaOH / tetrahydrofuran; methanol / 12 h / 20 °C

With sodium hydroxide; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;

DOI:10.1021/jm010872r

upstream raw materials:

3-[N-[2-benzoyl-4-(N^α-tert-butyloxycarbonyl-S-tritylcysteinylamino)phenyl]carbamoyl]propionic acid methyl ester

N-tert-butyloxycarbonyl-S-trityl-L-cysteine

2-amino-5-nitrobenzophenone

3-[N-(4-amino-2-benzoylphenyl)carbamoyl]propionic acid methyl ester

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