4-(1,5-bis(4-methoxyphenyl)oxazol-2-yl)-4-propyl-1-(N-hydroxy-N-methylcarbamoyl)piperidine

Base Information

Chemical Name:4-(1,5-bis(4-methoxyphenyl)oxazol-2-yl)-4-propyl-1-(N-hydroxy-N-methylcarbamoyl)piperidine
CAS No.:951743-90-1
Molecular Formula:C₂₇H₃₃N₃O₅
Molecular Weight:479.576
Hs Code.:

Synonyms:4-(1,5-bis(4-methoxyphenyl)oxazol-2-yl)-4-propyl-1-(N-hydroxy-N-methylcarbamoyl)piperidine

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Chemical Property of 4-(1,5-bis(4-methoxyphenyl)oxazol-2-yl)-4-propyl-1-(N-hydroxy-N-methylcarbamoyl)piperidine

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Technology Process of 4-(1,5-bis(4-methoxyphenyl)oxazol-2-yl)-4-propyl-1-(N-hydroxy-N-methylcarbamoyl)piperidine

There total 7 articles about 4-(1,5-bis(4-methoxyphenyl)oxazol-2-yl)-4-propyl-1-(N-hydroxy-N-methylcarbamoyl)piperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 951743-89-8
4-allyl-4-(1,5-bis(4-methoxyphenyl)oxazol-2-yl)-1-(N-hydroxy-N-methylcarbamoyl)piperidine

: 951743-90-1
4-(1,5-bis(4-methoxyphenyl)oxazol-2-yl)-4-propyl-1-(N-hydroxy-N-methylcarbamoyl)piperidine

Guidance literature:: With hydrogen; palladium 10% on activated carbon; In ethanol; for 3h;

Reference yield:

: 676341-47-2
allyl 1-tert-butoxycarbonyl-4-piperidinecarboxylate

: 951743-90-1
4-(1,5-bis(4-methoxyphenyl)oxazol-2-yl)-4-propyl-1-(N-hydroxy-N-methylcarbamoyl)piperidine

Guidance literature:: Multi-step reaction with 6 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / -78 °C

1.2: 1 h / -78 - 20 °C

2.1: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran; toluene / 3 h / 20 °C

3.1: ammonium acetate; acetic acid / 15 h / 60 °C

4.1: trifluoroacetic acid / dichloromethane / 2 h

4.2: 6 h / 0 - 20 °C

5.1: triethylamine / tetrahydrofuran / 15 h / 60 °C

6.1: hydrogen / palladium 10% on activated carbon / ethanol / 3 h

With di-isopropyl azodicarboxylate; ammonium acetate; hydrogen; acetic acid; triethylamine; triphenylphosphine; trifluoroacetic acid; lithium hexamethyldisilazane; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; dichloromethane; toluene;

Reference yield:

: 951745-39-4
(1,2-bis(4-methoxyphenyl)-2-oxoethyl) 1-tert-butoxycarbonyl-4-allyl-4-piperidinecarboxylate

: 951743-90-1
4-(1,5-bis(4-methoxyphenyl)oxazol-2-yl)-4-propyl-1-(N-hydroxy-N-methylcarbamoyl)piperidine

Guidance literature:: Multi-step reaction with 4 steps

1.1: ammonium acetate; acetic acid / 15 h / 60 °C

2.1: trifluoroacetic acid / dichloromethane / 2 h

2.2: 6 h / 0 - 20 °C

3.1: triethylamine / tetrahydrofuran / 15 h / 60 °C

4.1: hydrogen / palladium 10% on activated carbon / ethanol / 3 h

With ammonium acetate; hydrogen; acetic acid; triethylamine; trifluoroacetic acid; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; dichloromethane;