N-(3-chloro-5-oxo-5H-benzo[4,5]cyclohepta[1,2-b]pyridin-7-yl)-N-(2,4-dimethoxybenzyl)ethenesulfonamide

Base Information

Chemical Name:N-(3-chloro-5-oxo-5H-benzo[4,5]cyclohepta[1,2-b]pyridin-7-yl)-N-(2,4-dimethoxybenzyl)ethenesulfonamide
CAS No.:1309960-89-1
Molecular Formula:C₂₅H₂₁ClN₂O₅S
Molecular Weight:496.971
Hs Code.:

Synonyms:N-(3-chloro-5-oxo-5H-benzo[4,5]cyclohepta[1,2-b]pyridin-7-yl)-N-(2,4-dimethoxybenzyl)ethenesulfonamide

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Chemical Property of N-(3-chloro-5-oxo-5H-benzo[4,5]cyclohepta[1,2-b]pyridin-7-yl)-N-(2,4-dimethoxybenzyl)ethenesulfonamide

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Technology Process of N-(3-chloro-5-oxo-5H-benzo[4,5]cyclohepta[1,2-b]pyridin-7-yl)-N-(2,4-dimethoxybenzyl)ethenesulfonamide

There total 6 articles about N-(3-chloro-5-oxo-5H-benzo[4,5]cyclohepta[1,2-b]pyridin-7-yl)-N-(2,4-dimethoxybenzyl)ethenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 917878-68-3
3-chloro-7-[(2,4-dimethoxybenzyl)amino]-5H-benzo[4,5]cyclohepta[1,2-b]pyridin-5-one

: 1622-32-8
2-Chloroethanesulfonyl chloride

: 1309960-89-1
N-(3-chloro-5-oxo-5H-benzo[4,5]cyclohepta[1,2-b]pyridin-7-yl)-N-(2,4-dimethoxybenzyl)ethenesulfonamide

Guidance literature:: With 4-methyl-morpholine; In dichloromethane; at 0 - 20 ℃; Inert atmosphere;
DOI:10.1021/jm200112k

Reference yield:

: 917878-65-0
7-bromo-3-chloro-5H-benzo[4,5]cyclohepta[1,2-b]pyridin-5-one

: 1309960-89-1
N-(3-chloro-5-oxo-5H-benzo[4,5]cyclohepta[1,2-b]pyridin-7-yl)-N-(2,4-dimethoxybenzyl)ethenesulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; sodium t-butanolate / 1,4-dioxane / 100 °C / Inert atmosphere

2: 4-methyl-morpholine / dichloromethane / 0 - 20 °C / Inert atmosphere

With 4-methyl-morpholine; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; sodium t-butanolate; In 1,4-dioxane; dichloromethane;
DOI:10.1021/jm200112k

Reference yield:

: 917942-73-5
C₁₄H₉BrClNO₂

: 1309960-89-1
N-(3-chloro-5-oxo-5H-benzo[4,5]cyclohepta[1,2-b]pyridin-7-yl)-N-(2,4-dimethoxybenzyl)ethenesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1: polyphosphoric acid / 200 °C / Inert atmosphere

2: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; sodium t-butanolate / 1,4-dioxane / 100 °C / Inert atmosphere

3: 4-methyl-morpholine / dichloromethane / 0 - 20 °C / Inert atmosphere

With 4-methyl-morpholine; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; sodium t-butanolate; In 1,4-dioxane; dichloromethane;
DOI:10.1021/jm200112k