tert-butyl (S)-5-(benzyloxy)-1-(chloromethyl)-9-methyl-1,2-dihydro-3H-benzo[e]indole-3-carboxylate

Base Information

Chemical Name:tert-butyl (S)-5-(benzyloxy)-1-(chloromethyl)-9-methyl-1,2-dihydro-3H-benzo[e]indole-3-carboxylate
CAS No.:945864-47-1
Molecular Formula:C₂₆H₂₈ClNO₃
Molecular Weight:437.966
Hs Code.:

Synonyms:tert-butyl (S)-5-(benzyloxy)-1-(chloromethyl)-9-methyl-1,2-dihydro-3H-benzo[e]indole-3-carboxylate

Suppliers and Price of tert-butyl (S)-5-(benzyloxy)-1-(chloromethyl)-9-methyl-1,2-dihydro-3H-benzo[e]indole-3-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

AK Scientific
Tert-butyl1-(chloromethyl)-9-methyl-5-phenylmethoxy-1,2-dihydrobenzo[e]indole-3-carboxylate
100mg
$ 1747.00

Total 1 raw suppliers

Chemical Property of tert-butyl (S)-5-(benzyloxy)-1-(chloromethyl)-9-methyl-1,2-dihydro-3H-benzo[e]indole-3-carboxylate

Chemical Property:

Boiling Point:577.4±50.0 °C(Predicted)
Density:1.202±0.06 g/cm3(Predicted)

Purity/Quality:

99% ^*data from raw suppliers

Tert-butyl1-(chloromethyl)-9-methyl-5-phenylmethoxy-1,2-dihydrobenzo[e]indole-3-carboxylate ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Uses (S)-5-(benzyloxy)-1-(chloromethyl)-9-methyl-1,2-dihydro-3H-benzo[e]indole-3-carboxylate is an important organic intermediate to synthetize substituted benzo[e]indole products.

Technology Process of tert-butyl (S)-5-(benzyloxy)-1-(chloromethyl)-9-methyl-1,2-dihydro-3H-benzo[e]indole-3-carboxylate

There total 10 articles about tert-butyl (S)-5-(benzyloxy)-1-(chloromethyl)-9-methyl-1,2-dihydro-3H-benzo[e]indole-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: (S)-tert-butyl 5-(benzyloxy)-9-methyl-1-(((methylsulfonyl)oxy)methyl)-1H-benzo[e]indole-3(2H)-carboxylate

: 945864-47-1
tert-butyl (S)-5-(benzyloxy)-1-(chloromethyl)-9-methyl-1,2-dihydro-3H-benzo[e]indole-3-carboxylate

Guidance literature:: With lithium chloride; In N,N-dimethyl-formamide; at 80 ℃; for 1.5h;
DOI:10.1021/mp500781a

Reference yield:

: tert-butyl (4-(benzyloxy)-8-methylnaphthalen-2-yl)carbamate

: 945864-47-1
tert-butyl (S)-5-(benzyloxy)-1-(chloromethyl)-9-methyl-1,2-dihydro-3H-benzo[e]indole-3-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: N-Bromosuccinimide / tetrahydrofuran / -10 °C

2.1: potassium tert-butylate / tetrahydrofuran / 10 °C

2.2: 3 h / 25 °C

3.1: n-butyllithium / tetrahydrofuran; hexane / 0.17 h / -25 - -20 °C / Inert atmosphere

4.1: triethylamine / dichloromethane / 1.5 h / 0 - 5 °C

5.1: lithium chloride / N,N-dimethyl-formamide / 1.5 h / 80 °C

With N-Bromosuccinimide; n-butyllithium; potassium tert-butylate; triethylamine; lithium chloride; In tetrahydrofuran; hexane; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/mp500781a

Reference yield:

: tert-butyl (4-(benzyloxy)-1-bromo-8-methylnaphthalen-2-yl)carbamate

: 945864-47-1
tert-butyl (S)-5-(benzyloxy)-1-(chloromethyl)-9-methyl-1,2-dihydro-3H-benzo[e]indole-3-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium tert-butylate / tetrahydrofuran / 10 °C

1.2: 3 h / 25 °C

2.1: n-butyllithium / tetrahydrofuran; hexane / 0.17 h / -25 - -20 °C / Inert atmosphere

3.1: triethylamine / dichloromethane / 1.5 h / 0 - 5 °C

4.1: lithium chloride / N,N-dimethyl-formamide / 1.5 h / 80 °C

With n-butyllithium; potassium tert-butylate; triethylamine; lithium chloride; In tetrahydrofuran; hexane; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/mp500781a