(S)-N-(2-(1-(chloromethyl)-5-hydroxy-9-methyl-2,3-dihydro-1H-benzo[e]indole-3-carbonyl)-imidazo[1,2-a]pyridin-6-yl)-4-(methoxymethoxy)benzamide

Base Information

Chemical Name:(S)-N-(2-(1-(chloromethyl)-5-hydroxy-9-methyl-2,3-dihydro-1H-benzo[e]indole-3-carbonyl)-imidazo[1,2-a]pyridin-6-yl)-4-(methoxymethoxy)benzamide
CAS No.:1345681-72-2
Molecular Formula:C₃₁H₂₇ClN₄O₅
Molecular Weight:571.032
Hs Code.:

Synonyms:(S)-N-(2-(1-(chloromethyl)-5-hydroxy-9-methyl-2,3-dihydro-1H-benzo[e]indole-3-carbonyl)-imidazo[1,2-a]pyridin-6-yl)-4-(methoxymethoxy)benzamide

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Chemical Property of (S)-N-(2-(1-(chloromethyl)-5-hydroxy-9-methyl-2,3-dihydro-1H-benzo[e]indole-3-carbonyl)-imidazo[1,2-a]pyridin-6-yl)-4-(methoxymethoxy)benzamide

Chemical Property:

Purity/Quality:: 99%+ ^*data from raw suppliers

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Technology Process of (S)-N-(2-(1-(chloromethyl)-5-hydroxy-9-methyl-2,3-dihydro-1H-benzo[e]indole-3-carbonyl)-imidazo[1,2-a]pyridin-6-yl)-4-(methoxymethoxy)benzamide

There total 20 articles about (S)-N-(2-(1-(chloromethyl)-5-hydroxy-9-methyl-2,3-dihydro-1H-benzo[e]indole-3-carbonyl)-imidazo[1,2-a]pyridin-6-yl)-4-(methoxymethoxy)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: (S)-N-(2-(5-(benzyloxy)-1-(chloromethyl)-9-methyl-2,3-dihydro-1H-benzo[e]indole-3-carbonyl)imidazo[1,2-a]pyridin-6-yl)-4-(methoxymethoxy)benzamide

: 1345681-72-2
(S)-N-(2-(1-(chloromethyl)-5-hydroxy-9-methyl-2,3-dihydro-1H-benzo[e]indole-3-carbonyl)-imidazo[1,2-a]pyridin-6-yl)-4-(methoxymethoxy)benzamide

Guidance literature:: With palladium 10% on activated carbon; ammonium formate; In tetrahydrofuran; methanol; at 20 ℃; for 3h;
DOI:10.1021/mp500781a

Reference yield:

: tert-butyl (4-(benzyloxy)-8-methylnaphthalen-2-yl)carbamate

: 1345681-72-2
(S)-N-(2-(1-(chloromethyl)-5-hydroxy-9-methyl-2,3-dihydro-1H-benzo[e]indole-3-carbonyl)-imidazo[1,2-a]pyridin-6-yl)-4-(methoxymethoxy)benzamide

Guidance literature:: Multi-step reaction with 8 steps

1.1: N-Bromosuccinimide / tetrahydrofuran / -10 °C

2.1: potassium tert-butylate / tetrahydrofuran / 10 °C

2.2: 3 h / 25 °C

3.1: n-butyllithium / tetrahydrofuran; hexane / 0.17 h / -25 - -20 °C / Inert atmosphere

4.1: triethylamine / dichloromethane / 1.5 h / 0 - 5 °C

5.1: lithium chloride / N,N-dimethyl-formamide / 1.5 h / 80 °C

6.1: hydrogenchloride / 1,4-dioxane / 4 h

7.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl acetamide / 18 h / 0 - 20 °C

8.1: palladium 10% on activated carbon; ammonium formate / methanol; tetrahydrofuran / 3 h / 20 °C

With hydrogenchloride; N-Bromosuccinimide; n-butyllithium; palladium 10% on activated carbon; potassium tert-butylate; ammonium formate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; lithium chloride; In tetrahydrofuran; 1,4-dioxane; methanol; hexane; dichloromethane; N,N-dimethyl acetamide; N,N-dimethyl-formamide;
DOI:10.1021/mp500781a

Reference yield:

: tert-butyl (4-(benzyloxy)-1-bromo-8-methylnaphthalen-2-yl)carbamate

: 1345681-72-2
(S)-N-(2-(1-(chloromethyl)-5-hydroxy-9-methyl-2,3-dihydro-1H-benzo[e]indole-3-carbonyl)-imidazo[1,2-a]pyridin-6-yl)-4-(methoxymethoxy)benzamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: potassium tert-butylate / tetrahydrofuran / 10 °C

1.2: 3 h / 25 °C

2.1: n-butyllithium / tetrahydrofuran; hexane / 0.17 h / -25 - -20 °C / Inert atmosphere

3.1: triethylamine / dichloromethane / 1.5 h / 0 - 5 °C

4.1: lithium chloride / N,N-dimethyl-formamide / 1.5 h / 80 °C

5.1: hydrogenchloride / 1,4-dioxane / 4 h

6.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl acetamide / 18 h / 0 - 20 °C

7.1: palladium 10% on activated carbon; ammonium formate / methanol; tetrahydrofuran / 3 h / 20 °C

With hydrogenchloride; n-butyllithium; palladium 10% on activated carbon; potassium tert-butylate; ammonium formate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; lithium chloride; In tetrahydrofuran; 1,4-dioxane; methanol; hexane; dichloromethane; N,N-dimethyl acetamide; N,N-dimethyl-formamide;
DOI:10.1021/mp500781a