N-(1-cyanocyclopropyl)-11-(cyclohexylmethoxy)undecanamide

Base Information

• Chemical Name: N-(1-cyanocyclopropyl)-11-(cyclohexylmethoxy)undecanamide
• CAS No.: 1307309-92-7
• Molecular Formula: C₂₂H₃₈N₂O₂
• Molecular Weight: 362.556
• Mol file: 1307309-92-7.mol

Synonyms:N-(1-cyanocyclopropyl)-11-(cyclohexylmethoxy)undecanamide

Chemical Property of N-(1-cyanocyclopropyl)-11-(cyclohexylmethoxy)undecanamide

Chemical Property:

Purity/Quality:

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• Hazard Codes: 

MSDS Files:

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Technology Process of N-(1-cyanocyclopropyl)-11-(cyclohexylmethoxy)undecanamide

There total 2 articles about N-(1-cyanocyclopropyl)-11-(cyclohexylmethoxy)undecanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

11-(cyclohexylmethoxy)undecanoic acid (1307309-91-6) + 1-amino-1-cyclopropanecarbonitrile hydrochloride (127946-77-4) → N-(1-cyanocyclopropyl)-11-(cyclohexylmethoxy)undecanamide (1307309-92-7)

Guidance literature:

With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 4h; Inert atmosphere;

DOI:10.1021/jm2001053

Reference yield:

cyclohexylmethyl alcohol (100-49-2) → N-(1-cyanocyclopropyl)-11-(cyclohexylmethoxy)undecanamide (1307309-92-7)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.75 h / 0 - 20 °C / Inert atmosphere

1.2: 12 h / Inert atmosphere

2.1: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane / 4 h / 20 °C / Inert atmosphere

With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; sodium hydride; N-ethyl-N,N-diisopropylamine; In dichloromethane; N,N-dimethyl-formamide; mineral oil; 1.1: Williamson synthesis / 1.2: Williamson synthesis;

DOI:10.1021/jm2001053

Reference yield: 68.0%

N-(1-cyanocyclopropyl)-11-(cyclohexylmethoxy)undecanamide (1307309-92-7) → N-(1-carbamimidoylcyclopropyl)-11-(cyclohexylmethoxy)undecanamide hydrochloride (1307309-93-8)

Guidance literature:

N-(1-cyanocyclopropyl)-11-(cyclohexylmethoxy)undecanamide; With sodium methylate; In methanol; at 20 - 50 ℃; for 24h; Inert atmosphere;

With ammonium chloride; In methanol; at 50 ℃; Inert atmosphere;

DOI:10.1021/jm2001053

upstream raw materials:

11-(cyclohexylmethoxy)undecanoic acid

1-amino-1-cyclopropanecarbonitrile hydrochloride

cyclohexylmethyl alcohol

Downstream raw materials:

N-(1-carbamimidoylcyclopropyl)-11-(cyclohexylmethoxy)undecanamide hydrochloride

Refernces