Benzamide, N-(3-phenyl-1-(4-phenyl-2-thiazolyl)-1H-pyrazol-5-yl)-

Base Information

• Chemical Name: Benzamide, N-(3-phenyl-1-(4-phenyl-2-thiazolyl)-1H-pyrazol-5-yl)-
• CAS No.: 74101-25-0
• Molecular Formula: C₂₅H₁₈N₄OS
• Molecular Weight: 422.51
• DSSTox Substance ID: DTXSID30225027
• Wikidata: Q83103906
• Mol file: 74101-25-0.mol

Synonyms:74101-25-0;BRN 1177469;Benzamide, N-(3-phenyl-1-(4-phenyl-2-thiazolyl)-1H-pyrazol-5-yl)-;N-(3-Phenyl-1-(4-phenyl-2-thiazolyl)-1H-pyrazol-5-yl)benzamide;N-(3-Phenyl-1-(4-phenylthiazol-2-yl)-1H-pyrazol-5-yl)benzamide;C25H18N4OS;DTXSID30225027;C25-H18-N4-O-S;LS-27359

Chemical Property of Benzamide, N-(3-phenyl-1-(4-phenyl-2-thiazolyl)-1H-pyrazol-5-yl)-

Chemical Property:

• PSA: 88.05000
• Density: 1.28g/cm³
• LogP: 5.98810
• XLogP3: 5.7
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 5
• Exact Mass: 422.12013238
• Heavy Atom Count: 31
• Complexity: 586

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)C2=NN(C(=C2)NC(=O)C3=CC=CC=C3)C4=NC(=CS4)C5=CC=CC=C5

Technology Process of Benzamide, N-(3-phenyl-1-(4-phenyl-2-thiazolyl)-1H-pyrazol-5-yl)-

There total 4 articles about Benzamide, N-(3-phenyl-1-(4-phenyl-2-thiazolyl)-1H-pyrazol-5-yl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-hydrazino-4-phenylthiazole (34176-52-8) → N-[5-phenyl-2-(4-phenyl-thiazol-2-yl)-2H-pyrazol-3-yl]-benzamide (74101-25-0)

Guidance literature:

Multi-step reaction with 2 steps

1: ethanol / 0.67 h / Heating

2: aq. NaOH

With sodium hydroxide; In ethanol;

Reference yield:

α-bromoacetophenone (70-11-1) → N-[5-phenyl-2-(4-phenyl-thiazol-2-yl)-2H-pyrazol-3-yl]-benzamide (74101-25-0)

Guidance literature:

Multi-step reaction with 2 steps

1: AcOH / ethanol / 2 h / Heating

2: aq. NaOH

With sodium hydroxide; acetic acid; In ethanol;

Reference yield:

5-amino-3-phenyl-pyrazole-1-carbothioic acid amide (54476-07-2) → N-[5-phenyl-2-(4-phenyl-thiazol-2-yl)-2H-pyrazol-3-yl]-benzamide (74101-25-0)

Guidance literature:

Multi-step reaction with 2 steps

1: AcOH / ethanol / 2 h / Heating

2: aq. NaOH

With sodium hydroxide; acetic acid; In ethanol;

upstream raw materials:

5-phenyl-2-(4-phenyl-thiazol-2-yl)-2H-pyrazol-3-ylamine

benzoyl chloride

2-hydrazino-4-phenylthiazole

α-bromoacetophenone