Methanesulfonic acid (1R,2R,3S,4S)-2-(tert-butyl-diphenyl-silanyloxymethyl)-3-fluoro-4-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-cyclopentyl ester

Base Information

Chemical Name:Methanesulfonic acid (1R,2R,3S,4S)-2-(tert-butyl-diphenyl-silanyloxymethyl)-3-fluoro-4-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-cyclopentyl ester
CAS No.:135387-48-3
Molecular Formula:C₂₈H₃₅FN₂O₆SSi
Molecular Weight:574.746
Hs Code.:

Methanesulfonic acid (1R,2R,3S,4S)-2-(tert-butyl-diphenyl-silanyloxymethyl)-3-fluoro-4-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-cyclopentyl ester

Synonyms:Methanesulfonic acid (1R,2R,3S,4S)-2-(tert-butyl-diphenyl-silanyloxymethyl)-3-fluoro-4-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-cyclopentyl ester

Suppliers and Price of Methanesulfonic acid (1R,2R,3S,4S)-2-(tert-butyl-diphenyl-silanyloxymethyl)-3-fluoro-4-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-cyclopentyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of Methanesulfonic acid (1R,2R,3S,4S)-2-(tert-butyl-diphenyl-silanyloxymethyl)-3-fluoro-4-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-cyclopentyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of Methanesulfonic acid (1R,2R,3S,4S)-2-(tert-butyl-diphenyl-silanyloxymethyl)-3-fluoro-4-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-cyclopentyl ester

There total 13 articles about Methanesulfonic acid (1R,2R,3S,4S)-2-(tert-butyl-diphenyl-silanyloxymethyl)-3-fluoro-4-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-cyclopentyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 135387-39-2,135500-90-2
1-[(1S,2S,3R,4R)-3-(tert-Butyl-diphenyl-silanyloxymethyl)-2-fluoro-4-hydroxy-cyclopentyl]-5-methyl-1H-pyrimidine-2,4-dione

: 124-63-0
methanesulfonyl chloride

: 135387-48-3
Methanesulfonic acid (1R,2R,3S,4S)-2-(tert-butyl-diphenyl-silanyloxymethyl)-3-fluoro-4-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-cyclopentyl ester

Guidance literature:: With pyridine; for 8h; Ambient temperature;

Reference yield:

: 132151-65-6
(E)-3-methoxy-2-methylacryloyl isocyanate

: 135387-48-3
1-<(1β,2β,3β,4β)-3-(tert-butyldiphenylsilyloxymethyl)-2-fluoro-4-(methylsulphonyloxy)cyclopentyl>-5-methylpyrimidine-2,4(1H,3H)-dione

Guidance literature:: Multi-step reaction with 4 steps

1: 75 percent / 1) DMF, benzene, -20 deg C to room temp., 1 h, 2) room temp., 15 h

2: 2) imidazole / 1) 1,4-dioxane, 4 M aq. hydrochloric acid, reflux, 1.5 h, 2) DMF, room temp., 1 h

3: 69 mg / H₂ / 20percent Pd(OH)2/C / ethyl acetate; ethanol / 24 h / 760 Torr / Ambient temperature

4: 28.8 mg / pyridine / 8 h

With pyridine; 1H-imidazole; hydrogen; palladium dihydroxide; In ethanol; ethyl acetate;

Reference yield:

: 132151-65-6
(E)-3-methoxy-2-methylacryloyl isocyanate

: 135387-48-3
Methanesulfonic acid (1R,2R,3S,4S)-2-(tert-butyl-diphenyl-silanyloxymethyl)-3-fluoro-4-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-cyclopentyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 98 percent / dimethylformamide; benzene / 1) -20 deg C to room temperature, 1 h, 2) room temperature, 15 h

2: 1) 4 M aq. HCl, 2) imidazole / 1) 1,4-dioxane, reflux, 1.5 h, 2) DMF, room temperature, 1 h

3: 75 percent / H₂ / 20percent Pd(OH)2/C / ethyl acetate; ethanol / 24 h / 760 Torr / Ambient temperature

4: 97 percent / pyridine / 8 h / Ambient temperature

With pyridine; 1H-imidazole; hydrogenchloride; hydrogen; palladium dihydroxide; In ethanol; ethyl acetate; N,N-dimethyl-formamide; benzene;