2-chloro-N,N-dimethyl-2-phenylacetamide

Base Information

• Chemical Name: 2-chloro-N,N-dimethyl-2-phenylacetamide
• CAS No.: 65117-30-8
• Molecular Formula: C₁₀H₁₂ClNO
• Molecular Weight: 197.664
• Hs Code.: 2924299090
• DSSTox Substance ID: DTXSID50407141
• Mol file: 65117-30-8.mol

Synonyms:2-chloro-N,N-dimethyl-2-phenylacetamide;65117-30-8;DTXSID50407141;AKOS000118121;AKOS016889112;NCGC00328175-01;EN300-13829;AB01323469-02;Z94598472;F8880-6286

Chemical Property of 2-chloro-N,N-dimethyl-2-phenylacetamide

Chemical Property:

• Vapor Pressure: 0.00162mmHg at 25°C
• Boiling Point: 294.5°C at 760 mmHg
• Flash Point: 131.9°C
• PSA: 20.31000
• Density: 1.15g/cm³
• LogP: 2.05470
• XLogP3: 2
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 2
• Exact Mass: 197.0607417
• Heavy Atom Count: 13
• Complexity: 176

Purity/Quality:

99% ^*data from raw suppliers

2-Chloro-N,N-dimethyl-2-phenylacetamide 95%+ ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CN(C)C(=O)C(C1=CC=CC=C1)Cl

Technology Process of 2-chloro-N,N-dimethyl-2-phenylacetamide

There total 5 articles about 2-chloro-N,N-dimethyl-2-phenylacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N.N-Dimethyl-2-hydroxy-2-phenylthioacetamid (52417-38-6) → α-Chlorphenylacetamid (65117-30-8)

Guidance literature:

With thionyl chloride; sodium carbonate; In diethyl ether; Ambient temperature;

DOI:10.1021/jo971590v

Reference yield:

Chloro-phenyl-acetic acid (4755-72-0,39266-56-3) → (R)-chloro-phenyl-acetic acid dimethylamide (65117-30-8)

Guidance literature:

Multi-step reaction with 3 steps

1: (R)-1-phenyl-ethylamine

2: thionyl chloride

With thionyl chloride; (R)-1-phenyl-ethyl-amine;

Reference yield:

(R)-2-chloro-2-phenylacetic acid (43195-94-4) → (R)-chloro-phenyl-acetic acid dimethylamide (65117-30-8)

Guidance literature:

Multi-step reaction with 2 steps

1: thionyl chloride

With thionyl chloride;

upstream raw materials:

N_.N-Dimethyl-2-hydroxy-2-phenylthioacetamid

(R)-chloro-phenyl-acetic acid-chloride

Chloro-phenyl-acetic acid

(R)-2-chloro-2-phenylacetic acid