3'-amino-6-N-benzoyl-5'-O-(tert-butyldimethylsilyl)-2',3'-dideoxyadenosine

Base Information

Chemical Name:3'-amino-6-N-benzoyl-5'-O-(tert-butyldimethylsilyl)-2',3'-dideoxyadenosine
CAS No.:195375-61-2
Molecular Formula:C₂₃H₃₂N₆O₃Si
Molecular Weight:468.631
Hs Code.:

Synonyms:3'-amino-6-N-benzoyl-5'-O-(tert-butyldimethylsilyl)-2',3'-dideoxyadenosine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3'-amino-6-N-benzoyl-5'-O-(tert-butyldimethylsilyl)-2',3'-dideoxyadenosine

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Technology Process of 3'-amino-6-N-benzoyl-5'-O-(tert-butyldimethylsilyl)-2',3'-dideoxyadenosine

There total 10 articles about 3'-amino-6-N-benzoyl-5'-O-(tert-butyldimethylsilyl)-2',3'-dideoxyadenosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 195375-60-1
3'-azido-6-N-benzoyl-5'-O-(tert-butyldimethylsilyl)-2',3'-dideoxyadenosine

: 195375-61-2
3'-amino-6-N-benzoyl-5'-O-(tert-butyldimethylsilyl)-2',3'-dideoxyadenosine

Guidance literature:: With palladium on activated charcoal; hydrogen; In methanol; at 20 ℃; for 20h; under 750.075 Torr; Inert atmosphere;
DOI:10.3762/bjoc.11.8

Reference yield:

: 195375-62-3
N-{9-[(2R,4S,5S)-5-(tert-Butyl-dimethyl-silanyloxymethyl)-4-(trityl-amino)-tetrahydro-furan-2-yl]-9H-purin-6-yl}-benzamide

: 195375-61-2
3'-amino-6-N-benzoyl-5'-O-(tert-butyldimethylsilyl)-2',3'-dideoxyadenosine

Guidance literature:: With acetic acid; In water; at 20 ℃; for 1h;

Reference yield:

: 195375-59-8
6-N-benzoyl-5'-O-(tert-butyldimethylsilyl)-2'-deoxy-3'-xylo-adenosine

: 195375-61-2
3'-amino-6-N-benzoyl-5'-O-(tert-butyldimethylsilyl)-2',3'-dideoxyadenosine

Guidance literature:: Multi-step reaction with 2 steps

1: 18.8 g / LiN₃, PPh₃, DEAD / dimethylformamide / 6 h / Ambient temperature

2: 68 percent / H₂ / 10percent Pd/C / ethanol; CH₂Cl₂

With lithium azide; hydrogen; triphenylphosphine; diethylazodicarboxylate; palladium on activated charcoal; In ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jo970801t