O-benzylpolycarpine

Base Information

• Chemical Name: O-benzylpolycarpine
• CAS No.: 79659-48-6
• Molecular Formula: C₂₈H₂₉NO₆
• Molecular Weight: 475.541
• Mol file: 79659-48-6.mol

Synonyms:O-benzylpolycarpine

Chemical Property of O-benzylpolycarpine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of O-benzylpolycarpine

There total 6 articles about O-benzylpolycarpine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2'-hydroxy-3',4'-dimethoxyacetophenone (5396-18-9) → O-benzylpolycarpine (79659-48-6)

Guidance literature:

Multi-step reaction with 5 steps

1: 6.4 g / K₂CO₃ / acetone / Heating; overnight

2: 1.) Tl(NO₃)3 on Montmorillinite clay; 2.) sodium methoxide; aq. HCl / 1.) methylene chloride, room temperature, 1 h; 2.) methanol, H₂O, overnight

3: 94 percent / xylene / 18 h / Heating

4: POCl₃ / toluene / 2 h / Heating

5: sodium acetate / Ambient temperature; overnight

With hydrogenchloride; sodium methylate; sodium acetate; potassium carbonate; thallium(III) nitrate; trichlorophosphate; In acetone; toluene; xylene;

DOI:10.1002/jhet.5570180410

Reference yield:

2'-benzyloxy-3',4'-dimethoxyacetophenone (56774-68-6) → O-benzylpolycarpine (79659-48-6)

Guidance literature:

Multi-step reaction with 4 steps

1: 1.) Tl(NO₃)3 on Montmorillinite clay; 2.) sodium methoxide; aq. HCl / 1.) methylene chloride, room temperature, 1 h; 2.) methanol, H₂O, overnight

2: 94 percent / xylene / 18 h / Heating

3: POCl₃ / toluene / 2 h / Heating

4: sodium acetate / Ambient temperature; overnight

With hydrogenchloride; sodium methylate; sodium acetate; thallium(III) nitrate; trichlorophosphate; In toluene; xylene;

DOI:10.1002/jhet.5570180410

Reference yield:

2',3',4'-trimethoxyacetophenone (13909-73-4) → O-benzylpolycarpine (79659-48-6)

Guidance literature:

Multi-step reaction with 6 steps

1: 88 percent / BCl₃ / CH₂Cl₂ / 0.25 h / 0 °C

2: 6.4 g / K₂CO₃ / acetone / Heating; overnight

3: 1.) Tl(NO₃)3 on Montmorillinite clay; 2.) sodium methoxide; aq. HCl / 1.) methylene chloride, room temperature, 1 h; 2.) methanol, H₂O, overnight

4: 94 percent / xylene / 18 h / Heating

5: POCl₃ / toluene / 2 h / Heating

6: sodium acetate / Ambient temperature; overnight

With hydrogenchloride; sodium methylate; sodium acetate; boron trichloride; potassium carbonate; thallium(III) nitrate; trichlorophosphate; In dichloromethane; acetone; toluene; xylene;

DOI:10.1002/jhet.5570180410

upstream raw materials:

1-(2-Benzyloxy-3,4-dimethoxy-benzyl)-6,7-dimethoxy-3,4-dihydro-isoquinoline

formyl acetic anhydride

2'-hydroxy-3',4'-dimethoxyacetophenone

2'-benzyloxy-3',4'-dimethoxyacetophenone

Downstream raw materials:

polycarpine

Refernces